A p27(Kip1) mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation

Mitotic catastrophe occurs when cells enter mitosis with damaged DNA or excess centrosomes. Cells overexpressing the centrosome protein CP110 or depleted of cyclin F, which targets CP110 for destruction, have more than two centrosomes and undergo mitotic catastrophe. Our studies show centrosome redu...

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Detalles Bibliográficos
Autores principales: Sharma, S S, Ma, L, Bagui, T K, Forinash, K D, Pledger, W J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432229/
https://www.ncbi.nlm.nih.gov/pubmed/22158041
http://dx.doi.org/10.1038/onc.2011.550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432229/
https://www.ncbi.nlm.nih.gov/pubmed/22158041
http://dx.doi.org/10.1038/onc.2011.550

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