Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands

A mononuclear complex of Zn(II), [Zn(DIP)(2) (DMP)] (NO(3))(2) ·2H(2)O in which DIP is 4,7-diphenyl-1,10-phenanthroline and DMP is 4,4′-dimethyl-2,2′-bipyridine has been prepared and characterized by (1)HNMR spectroscopy, FT-IR, UV-Vis and elemental analysis techniques. DNA-binding properties of the...

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Detalles Bibliográficos
Autores principales: Shahabadi, Nahid, Mohammadi, Somaye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432521/
https://www.ncbi.nlm.nih.gov/pubmed/22956919
http://dx.doi.org/10.1155/2012/571913
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author Shahabadi, Nahid
Mohammadi, Somaye
author_facet Shahabadi, Nahid
Mohammadi, Somaye
author_sort Shahabadi, Nahid
collection PubMed
description A mononuclear complex of Zn(II), [Zn(DIP)(2) (DMP)] (NO(3))(2) ·2H(2)O in which DIP is 4,7-diphenyl-1,10-phenanthroline and DMP is 4,4′-dimethyl-2,2′-bipyridine has been prepared and characterized by (1)HNMR spectroscopy, FT-IR, UV-Vis and elemental analysis techniques. DNA-binding properties of the complex were studied using UV-vis spectra, circular dichroism (CD) spectra, fluorescence, cyclic voltammetry (CV), and viscosity measurements. The results indicate that this zinc(II) complex can intercalate into the stacked base pairs of DNA and compete with the strong intercalator ethidium bromide for the intercalative binding sites.
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spelling pubmed-34325212012-09-06 Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands Shahabadi, Nahid Mohammadi, Somaye Bioinorg Chem Appl Research Article A mononuclear complex of Zn(II), [Zn(DIP)(2) (DMP)] (NO(3))(2) ·2H(2)O in which DIP is 4,7-diphenyl-1,10-phenanthroline and DMP is 4,4′-dimethyl-2,2′-bipyridine has been prepared and characterized by (1)HNMR spectroscopy, FT-IR, UV-Vis and elemental analysis techniques. DNA-binding properties of the complex were studied using UV-vis spectra, circular dichroism (CD) spectra, fluorescence, cyclic voltammetry (CV), and viscosity measurements. The results indicate that this zinc(II) complex can intercalate into the stacked base pairs of DNA and compete with the strong intercalator ethidium bromide for the intercalative binding sites. Hindawi Publishing Corporation 2012 2012-08-26 /pmc/articles/PMC3432521/ /pubmed/22956919 http://dx.doi.org/10.1155/2012/571913 Text en Copyright © 2012 N. Shahabadi and S. Mohammadi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shahabadi, Nahid
Mohammadi, Somaye
Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands
title Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands
title_full Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands
title_fullStr Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands
title_full_unstemmed Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands
title_short Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands
title_sort synthesis characterization and dna interaction studies of a new zn(ii) complex containing different dinitrogen aromatic ligands
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432521/
https://www.ncbi.nlm.nih.gov/pubmed/22956919
http://dx.doi.org/10.1155/2012/571913
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