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Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala

In Latin America, onchocerciasis is targeted for elimination by 2012 through twice-yearly mass treatment of the eligible population with ivermectin. In Guatemala, two of the four historical endemic foci have demonstrated elimination of transmission, following World Health Organization guidelines. Us...

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Autores principales: Cruz-Ortiz, Nancy, Gonzalez, Rodrigo J., Lindblade, Kim A., Richards, Frank O., Sauerbrey, Mauricio, Zea-Flores, Guillermo, Dominguez, Alfredo, Oliva, Orlando, Catú, Eduardo, Rizzo, Nidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432545/
https://www.ncbi.nlm.nih.gov/pubmed/22970346
http://dx.doi.org/10.1155/2012/638429
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author Cruz-Ortiz, Nancy
Gonzalez, Rodrigo J.
Lindblade, Kim A.
Richards, Frank O.
Sauerbrey, Mauricio
Zea-Flores, Guillermo
Dominguez, Alfredo
Oliva, Orlando
Catú, Eduardo
Rizzo, Nidia
author_facet Cruz-Ortiz, Nancy
Gonzalez, Rodrigo J.
Lindblade, Kim A.
Richards, Frank O.
Sauerbrey, Mauricio
Zea-Flores, Guillermo
Dominguez, Alfredo
Oliva, Orlando
Catú, Eduardo
Rizzo, Nidia
author_sort Cruz-Ortiz, Nancy
collection PubMed
description In Latin America, onchocerciasis is targeted for elimination by 2012 through twice-yearly mass treatment of the eligible population with ivermectin. In Guatemala, two of the four historical endemic foci have demonstrated elimination of transmission, following World Health Organization guidelines. Using established guidelines ophthalmological, serological, and entomological evaluations were conducted in 2007-8 to determine the transmission status of onchocerciasis in the Huehuetenango focus. The prevalence of Onchocerca volvulus microfilariae in the anterior segment of the eye in 365 residents was 0% (95% confidence interval [CI] 0–0.8%), the prevalence of infection of O. volvulus in Simulium ochraceum among 8252 flies collected between November 2007 and April 2008 was 0% (95% CI 0–0.02%), and the prevalence of antibodies to a recombinant O. volvulus antigen in 3118 school age children was 0% (95% CI 0–0.1%). These results showed transmission interruption; thus, in 2009 mass treatment was halted and posttreatment surveillance began. To verify for potential recrudescence an entomological evaluation (from December 2010 to April 2011) was conducted during the 2nd and 3rd year of posttreatment surveillance. A total of 4587 S. ochraceum were collected, and the prevalence of infection of O. volvulus was 0% (95% CI 0–0.04%). Transmission of onchocerciasis in the Huehuetenango focus has been eliminated.
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spelling pubmed-34325452012-09-11 Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala Cruz-Ortiz, Nancy Gonzalez, Rodrigo J. Lindblade, Kim A. Richards, Frank O. Sauerbrey, Mauricio Zea-Flores, Guillermo Dominguez, Alfredo Oliva, Orlando Catú, Eduardo Rizzo, Nidia J Parasitol Res Research Article In Latin America, onchocerciasis is targeted for elimination by 2012 through twice-yearly mass treatment of the eligible population with ivermectin. In Guatemala, two of the four historical endemic foci have demonstrated elimination of transmission, following World Health Organization guidelines. Using established guidelines ophthalmological, serological, and entomological evaluations were conducted in 2007-8 to determine the transmission status of onchocerciasis in the Huehuetenango focus. The prevalence of Onchocerca volvulus microfilariae in the anterior segment of the eye in 365 residents was 0% (95% confidence interval [CI] 0–0.8%), the prevalence of infection of O. volvulus in Simulium ochraceum among 8252 flies collected between November 2007 and April 2008 was 0% (95% CI 0–0.02%), and the prevalence of antibodies to a recombinant O. volvulus antigen in 3118 school age children was 0% (95% CI 0–0.1%). These results showed transmission interruption; thus, in 2009 mass treatment was halted and posttreatment surveillance began. To verify for potential recrudescence an entomological evaluation (from December 2010 to April 2011) was conducted during the 2nd and 3rd year of posttreatment surveillance. A total of 4587 S. ochraceum were collected, and the prevalence of infection of O. volvulus was 0% (95% CI 0–0.04%). Transmission of onchocerciasis in the Huehuetenango focus has been eliminated. Hindawi Publishing Corporation 2012 2012-08-23 /pmc/articles/PMC3432545/ /pubmed/22970346 http://dx.doi.org/10.1155/2012/638429 Text en Copyright © 2012 Nancy Cruz-Ortiz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cruz-Ortiz, Nancy
Gonzalez, Rodrigo J.
Lindblade, Kim A.
Richards, Frank O.
Sauerbrey, Mauricio
Zea-Flores, Guillermo
Dominguez, Alfredo
Oliva, Orlando
Catú, Eduardo
Rizzo, Nidia
Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala
title Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala
title_full Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala
title_fullStr Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala
title_full_unstemmed Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala
title_short Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala
title_sort elimination of onchocerca volvulus transmission in the huehuetenango focus of guatemala
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432545/
https://www.ncbi.nlm.nih.gov/pubmed/22970346
http://dx.doi.org/10.1155/2012/638429
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