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Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging
BACKGROUND: The TAR hairpin is present at both the 5′ and 3′ end of the HIV-1 RNA genome. The 5′ element binds the viral Tat protein and is essential for Tat-mediated activation of transcription. We recently observed that complete TAR deletion is allowed in the context of an HIV-1 variant that does...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432602/ https://www.ncbi.nlm.nih.gov/pubmed/22828074 http://dx.doi.org/10.1186/1742-4690-9-59 |