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Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
RATIONALE: Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant cle...
Autores principales: | Malur, Anagha, Kavuru, Mani S, Marshall, Irene, Barna, Barbara P, Huizar, Isham, Karnekar, Reema, Thomassen, Mary Jane |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432632/ https://www.ncbi.nlm.nih.gov/pubmed/22697800 http://dx.doi.org/10.1186/1465-9921-13-46 |
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