Mouse ooplasm confers context-specific reprogramming capacity

Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfe...

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Autores principales: Chan, Michelle M., Smith, Zachary D., Egli, Dieter, Regev, Aviv, Meissner, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432711/
https://www.ncbi.nlm.nih.gov/pubmed/22902786
http://dx.doi.org/10.1038/ng.2382
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author Chan, Michelle M.
Smith, Zachary D.
Egli, Dieter
Regev, Aviv
Meissner, Alexander
author_facet Chan, Michelle M.
Smith, Zachary D.
Egli, Dieter
Regev, Aviv
Meissner, Alexander
author_sort Chan, Michelle M.
collection PubMed
description Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer such as germ-line associated promoters, as well as unique limitations that include certain repetitive element classes.
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spelling pubmed-34327112013-03-01 Mouse ooplasm confers context-specific reprogramming capacity Chan, Michelle M. Smith, Zachary D. Egli, Dieter Regev, Aviv Meissner, Alexander Nat Genet Article Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer such as germ-line associated promoters, as well as unique limitations that include certain repetitive element classes. 2012-08-19 2012-09 /pmc/articles/PMC3432711/ /pubmed/22902786 http://dx.doi.org/10.1038/ng.2382 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Chan, Michelle M.
Smith, Zachary D.
Egli, Dieter
Regev, Aviv
Meissner, Alexander
Mouse ooplasm confers context-specific reprogramming capacity
title Mouse ooplasm confers context-specific reprogramming capacity
title_full Mouse ooplasm confers context-specific reprogramming capacity
title_fullStr Mouse ooplasm confers context-specific reprogramming capacity
title_full_unstemmed Mouse ooplasm confers context-specific reprogramming capacity
title_short Mouse ooplasm confers context-specific reprogramming capacity
title_sort mouse ooplasm confers context-specific reprogramming capacity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432711/
https://www.ncbi.nlm.nih.gov/pubmed/22902786
http://dx.doi.org/10.1038/ng.2382
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AT meissneralexander mouseooplasmconferscontextspecificreprogrammingcapacity

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