Neutrophil extracellular traps: Is immunity the second function of chromatin?

Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of c...

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Detalles Bibliográficos
Autores principales: Brinkmann, Volker, Zychlinsky, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432757/
https://www.ncbi.nlm.nih.gov/pubmed/22945932
http://dx.doi.org/10.1083/jcb.201203170
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author Brinkmann, Volker
Zychlinsky, Arturo
author_facet Brinkmann, Volker
Zychlinsky, Arturo
author_sort Brinkmann, Volker
collection PubMed
description Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed “NETosis.” Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation.
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spelling pubmed-34327572013-03-03 Neutrophil extracellular traps: Is immunity the second function of chromatin? Brinkmann, Volker Zychlinsky, Arturo J Cell Biol Reviews Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed “NETosis.” Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation. The Rockefeller University Press 2012-09-03 /pmc/articles/PMC3432757/ /pubmed/22945932 http://dx.doi.org/10.1083/jcb.201203170 Text en © 2012 Brinkmann and Zychlinsky This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Brinkmann, Volker
Zychlinsky, Arturo
Neutrophil extracellular traps: Is immunity the second function of chromatin?
title Neutrophil extracellular traps: Is immunity the second function of chromatin?
title_full Neutrophil extracellular traps: Is immunity the second function of chromatin?
title_fullStr Neutrophil extracellular traps: Is immunity the second function of chromatin?
title_full_unstemmed Neutrophil extracellular traps: Is immunity the second function of chromatin?
title_short Neutrophil extracellular traps: Is immunity the second function of chromatin?
title_sort neutrophil extracellular traps: is immunity the second function of chromatin?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432757/
https://www.ncbi.nlm.nih.gov/pubmed/22945932
http://dx.doi.org/10.1083/jcb.201203170
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