Stuck in the middle: Rac, adhesion, and cytokinesis

Rho family small GTPases (Rac, RhoA, and Cdc42) function at the core of cytokinesis, the physical division of one cell into two. In this issue, Bastos et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201204107) identify a new role for Rac inhibition: to release cell adhesion at the division...

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Detalles Bibliográficos
Autores principales: Davies, Tim, Canman, Julie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432767/
https://www.ncbi.nlm.nih.gov/pubmed/22945931
http://dx.doi.org/10.1083/jcb.201207197
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author Davies, Tim
Canman, Julie C.
author_facet Davies, Tim
Canman, Julie C.
author_sort Davies, Tim
collection PubMed
description Rho family small GTPases (Rac, RhoA, and Cdc42) function at the core of cytokinesis, the physical division of one cell into two. In this issue, Bastos et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201204107) identify a new role for Rac inhibition: to release cell adhesion at the division plane and allow efficient constriction of the contractile ring. They show that the GTPase-activating protein, CYK4, suppresses equatorial cell substrate adhesion by inhibiting Rac and therefore its effectors ARFGEF7 and PAK1/2.
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spelling pubmed-34327672013-03-03 Stuck in the middle: Rac, adhesion, and cytokinesis Davies, Tim Canman, Julie C. J Cell Biol Reviews Rho family small GTPases (Rac, RhoA, and Cdc42) function at the core of cytokinesis, the physical division of one cell into two. In this issue, Bastos et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201204107) identify a new role for Rac inhibition: to release cell adhesion at the division plane and allow efficient constriction of the contractile ring. They show that the GTPase-activating protein, CYK4, suppresses equatorial cell substrate adhesion by inhibiting Rac and therefore its effectors ARFGEF7 and PAK1/2. The Rockefeller University Press 2012-09-03 /pmc/articles/PMC3432767/ /pubmed/22945931 http://dx.doi.org/10.1083/jcb.201207197 Text en © 2012 Davies and Canman This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Davies, Tim
Canman, Julie C.
Stuck in the middle: Rac, adhesion, and cytokinesis
title Stuck in the middle: Rac, adhesion, and cytokinesis
title_full Stuck in the middle: Rac, adhesion, and cytokinesis
title_fullStr Stuck in the middle: Rac, adhesion, and cytokinesis
title_full_unstemmed Stuck in the middle: Rac, adhesion, and cytokinesis
title_short Stuck in the middle: Rac, adhesion, and cytokinesis
title_sort stuck in the middle: rac, adhesion, and cytokinesis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432767/
https://www.ncbi.nlm.nih.gov/pubmed/22945931
http://dx.doi.org/10.1083/jcb.201207197
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