Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126

Cytarabine (ara-C) and gemcitabine (dFdC) are commonly used anticancer drugs, which depend on the equilibrative (ENT) and concentrative-nucleoside-transporters to enter the cell. To bypass transport-related drug resistance, lipophilic derivatives elacytarabine (CP-4055), ara-C-5′elaidic-acid-ester,...

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Detalles Bibliográficos
Autores principales: Adema, Auke D., Smid, Kees, Losekoot, Nienke, Honeywell, Richard J., Verheul, Henk M., Myhren, Finn, Sandvold, Marit L., Peters, Godefridus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432794/
https://www.ncbi.nlm.nih.gov/pubmed/22002019
http://dx.doi.org/10.1007/s10637-011-9756-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432794/
https://www.ncbi.nlm.nih.gov/pubmed/22002019
http://dx.doi.org/10.1007/s10637-011-9756-8

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