LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

The linear ubiquitin chain assembly complex (LUBAC) is a RING E3 ligase that regulates immune and inflammatory signalling pathways. Unlike classical RING E3 ligases, LUBAC determines the type of ubiquitin chain being formed, an activity normally associated with the E2 enzyme. We show that the RING-i...

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Detalles Bibliográficos
Autores principales: Stieglitz, Benjamin, Morris-Davies, Aylin C, Koliopoulos, Marios G, Christodoulou, Evangelos, Rittinger, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432797/
https://www.ncbi.nlm.nih.gov/pubmed/22791023
http://dx.doi.org/10.1038/embor.2012.105

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