A mathematical model for electrical stimulation of a monolayer of cardiac cells

BACKGROUND: The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue. METHODS: An equation governing the transmembrane potential, based on the continuity equation and...

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Detalles Bibliográficos
Autores principales: Srinivasan, Ranjini, Roth, Bradley J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC343291/
https://www.ncbi.nlm.nih.gov/pubmed/14746653
http://dx.doi.org/10.1186/1475-925X-3-1
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author Srinivasan, Ranjini
Roth, Bradley J
author_facet Srinivasan, Ranjini
Roth, Bradley J
author_sort Srinivasan, Ranjini
collection PubMed
description BACKGROUND: The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue. METHODS: An equation governing the transmembrane potential, based on the continuity equation and Ohm's law, is solved numerically using a finite difference technique. RESULTS: The sheet is depolarized under the stimulating electrode and is hyperpolarized on each side of the electrode along the fiber axis. CONCLUSIONS: The results are similar to those obtained previously by Sepulveda et al. (Biophys J, 55: 987–999, 1989) for stimulation of a two-dimensional sheet of tissue with no perfusing bath present.
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spelling pubmed-3432912004-02-21 A mathematical model for electrical stimulation of a monolayer of cardiac cells Srinivasan, Ranjini Roth, Bradley J Biomed Eng Online Research BACKGROUND: The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue. METHODS: An equation governing the transmembrane potential, based on the continuity equation and Ohm's law, is solved numerically using a finite difference technique. RESULTS: The sheet is depolarized under the stimulating electrode and is hyperpolarized on each side of the electrode along the fiber axis. CONCLUSIONS: The results are similar to those obtained previously by Sepulveda et al. (Biophys J, 55: 987–999, 1989) for stimulation of a two-dimensional sheet of tissue with no perfusing bath present. BioMed Central 2004-01-27 /pmc/articles/PMC343291/ /pubmed/14746653 http://dx.doi.org/10.1186/1475-925X-3-1 Text en Copyright © 2004 Srinivasan and Roth; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research
Srinivasan, Ranjini
Roth, Bradley J
A mathematical model for electrical stimulation of a monolayer of cardiac cells
title A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_full A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_fullStr A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_full_unstemmed A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_short A mathematical model for electrical stimulation of a monolayer of cardiac cells
title_sort mathematical model for electrical stimulation of a monolayer of cardiac cells
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC343291/
https://www.ncbi.nlm.nih.gov/pubmed/14746653
http://dx.doi.org/10.1186/1475-925X-3-1
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