Primary Small Cell Neuroendocrine Carcinoma of the Endometrium

BACKGROUND: Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium. CASE STUDY: A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the...

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Detalles Bibliográficos
Autores principales: Abaid, Lisa N., Cupp, John S., Brown, John V., Goldstein, Bram H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published online: August, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433003/
https://www.ncbi.nlm.nih.gov/pubmed/22949907
http://dx.doi.org/10.1159/000342006
Descripción
Sumario:BACKGROUND: Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium. CASE STUDY: A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the neoplasm exhibited positive immunoreactivity for synaptophysin, pancytokeratin and CD56 but was negative for CD3 and CD20. Prior to chemotherapy, a completion lymphadenectomy was indicated to determine the presence of nodal metastases. CONCLUSION: The prognosis of small cell neuroendocrine carcinoma of the endometrium is unfavorable but prompt detection with surgery and adjuvant therapy may confer a better clinical outcome.

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