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A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A
Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory keratosis that is clinically characterized by gradually developing reddish or orange extending plaques and keratotic follicular papules. In pediatric patients, we frequently hesitate to administer certain medications for treatment of PRP,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433028/ https://www.ncbi.nlm.nih.gov/pubmed/22949899 http://dx.doi.org/10.1159/000341946 |
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author | Koga, Monji Koga, Kaori Nakayama, Juichiro |
author_facet | Koga, Monji Koga, Kaori Nakayama, Juichiro |
author_sort | Koga, Monji |
collection | PubMed |
description | Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory keratosis that is clinically characterized by gradually developing reddish or orange extending plaques and keratotic follicular papules. In pediatric patients, we frequently hesitate to administer certain medications for treatment of PRP, specifically etretinate, systemic corticosteroids, and biologics recommended by previous studies. Although administration of high-dose vitamin A was described in a previous textbook of dermatology, details about the lower limits and treatment periods were not provided. We presented a pediatric case of PRP that was successfully controlled with minimum dosage of systemic vitamin A in the literature. Before and 14 days after beginning the therapy, both vitamin A levels of peripheral blood were within the normal range. We considered that the clinical efficacy may not be due to a supplementary effect of vitamin A, but to a pharmacological action because serum vitamin A was within the normal limits during the therapy. |
format | Online Article Text |
id | pubmed-3433028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-34330282012-09-04 A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A Koga, Monji Koga, Kaori Nakayama, Juichiro Case Rep Dermatol Published online: August, 2012 Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory keratosis that is clinically characterized by gradually developing reddish or orange extending plaques and keratotic follicular papules. In pediatric patients, we frequently hesitate to administer certain medications for treatment of PRP, specifically etretinate, systemic corticosteroids, and biologics recommended by previous studies. Although administration of high-dose vitamin A was described in a previous textbook of dermatology, details about the lower limits and treatment periods were not provided. We presented a pediatric case of PRP that was successfully controlled with minimum dosage of systemic vitamin A in the literature. Before and 14 days after beginning the therapy, both vitamin A levels of peripheral blood were within the normal range. We considered that the clinical efficacy may not be due to a supplementary effect of vitamin A, but to a pharmacological action because serum vitamin A was within the normal limits during the therapy. S. Karger AG 2012-08-09 /pmc/articles/PMC3433028/ /pubmed/22949899 http://dx.doi.org/10.1159/000341946 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: August, 2012 Koga, Monji Koga, Kaori Nakayama, Juichiro A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A |
title | A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A |
title_full | A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A |
title_fullStr | A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A |
title_full_unstemmed | A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A |
title_short | A Pediatric Case of Pityriasis Rubra Pilaris Successfully Treated with Low-Dose Vitamin A |
title_sort | pediatric case of pityriasis rubra pilaris successfully treated with low-dose vitamin a |
topic | Published online: August, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433028/ https://www.ncbi.nlm.nih.gov/pubmed/22949899 http://dx.doi.org/10.1159/000341946 |
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