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Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease

Extramammary Paget's disease is a rare cutaneous malignant neoplasm. Previous studies indicated the efficacy of docetaxel in advanced cases. The common side effects of docetaxel are usually tolerable and seldom life-threatening. We experienced a case of severe pseudomembranous colitis and neutr...

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Autores principales: Nonomura, Yumi, Otsuka, Atsushi, Endo, Yuichiro, Fujisawa, Akihiro, Tanioka, Miki, Kabashima, Kenji, Miyachi, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433030/
https://www.ncbi.nlm.nih.gov/pubmed/22949901
http://dx.doi.org/10.1159/000342069
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author Nonomura, Yumi
Otsuka, Atsushi
Endo, Yuichiro
Fujisawa, Akihiro
Tanioka, Miki
Kabashima, Kenji
Miyachi, Yoshiki
author_facet Nonomura, Yumi
Otsuka, Atsushi
Endo, Yuichiro
Fujisawa, Akihiro
Tanioka, Miki
Kabashima, Kenji
Miyachi, Yoshiki
author_sort Nonomura, Yumi
collection PubMed
description Extramammary Paget's disease is a rare cutaneous malignant neoplasm. Previous studies indicated the efficacy of docetaxel in advanced cases. The common side effects of docetaxel are usually tolerable and seldom life-threatening. We experienced a case of severe pseudomembranous colitis and neutropenic fever that developed just after the first cycle of docetaxel chemotherapy. To the best of our knowledge, there are few reports of pseudomembranous colitis associated with docetaxel administration for skin cancers. The patient showed complete resolution of her symptoms within 2 weeks with an oral metronidazole therapy. During the second and third cycles, the patient received docetaxel safely with lower doses. The present case indicated that pseudomembranous colitis should be included in the differential diagnosis when assessing patients who develop severe diarrhea during systemic chemotherapy with docetaxel.
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spelling pubmed-34330302012-09-04 Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease Nonomura, Yumi Otsuka, Atsushi Endo, Yuichiro Fujisawa, Akihiro Tanioka, Miki Kabashima, Kenji Miyachi, Yoshiki Case Rep Dermatol Published online: August, 2012 Extramammary Paget's disease is a rare cutaneous malignant neoplasm. Previous studies indicated the efficacy of docetaxel in advanced cases. The common side effects of docetaxel are usually tolerable and seldom life-threatening. We experienced a case of severe pseudomembranous colitis and neutropenic fever that developed just after the first cycle of docetaxel chemotherapy. To the best of our knowledge, there are few reports of pseudomembranous colitis associated with docetaxel administration for skin cancers. The patient showed complete resolution of her symptoms within 2 weeks with an oral metronidazole therapy. During the second and third cycles, the patient received docetaxel safely with lower doses. The present case indicated that pseudomembranous colitis should be included in the differential diagnosis when assessing patients who develop severe diarrhea during systemic chemotherapy with docetaxel. S. Karger AG 2012-08-22 /pmc/articles/PMC3433030/ /pubmed/22949901 http://dx.doi.org/10.1159/000342069 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: August, 2012
Nonomura, Yumi
Otsuka, Atsushi
Endo, Yuichiro
Fujisawa, Akihiro
Tanioka, Miki
Kabashima, Kenji
Miyachi, Yoshiki
Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease
title Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease
title_full Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease
title_fullStr Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease
title_full_unstemmed Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease
title_short Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease
title_sort clostridium difficile colitis and neutropenic fever associated with docetaxel chemotherapy in a patient with advanced extramammary paget's disease
topic Published online: August, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433030/
https://www.ncbi.nlm.nih.gov/pubmed/22949901
http://dx.doi.org/10.1159/000342069
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