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Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients

Systemic fungal infections typically occur in individuals who are seriously ill with recognized risk factors such as those frequently found in transplant recipients. Unfortunately, they are often diagnosed late, when the efficacy of the available treatments is low, often less than 50%, and the cost...

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Detalles Bibliográficos
Autores principales: Van Thiel, David H., George, Magdalena, Moore, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433127/
https://www.ncbi.nlm.nih.gov/pubmed/22966464
http://dx.doi.org/10.1155/2012/106923
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author Van Thiel, David H.
George, Magdalena
Moore, Christopher M.
author_facet Van Thiel, David H.
George, Magdalena
Moore, Christopher M.
author_sort Van Thiel, David H.
collection PubMed
description Systemic fungal infections typically occur in individuals who are seriously ill with recognized risk factors such as those frequently found in transplant recipients. Unfortunately, they are often diagnosed late, when the efficacy of the available treatments is low, often less than 50%, and the cost in terms of lives lost, hospital length of stay, and total hospital costs is substantially increased. The application of antifungal therapies associated with reported efficacy rates greater than 50% are those used prophylactically. When used prophylactically, these infections are reduced in greater than 95% of the expected cases. The choice of a prophylactic agent should be based upon its ease of administration, lack of adverse effects, reduced likelihood of potential drug interactions, and its efficacy in patients with established risk factors and comorbid disease processes that include renal, hepatic, and chronic pulmonary disease. The indications for the use of currently available antifungal agents, their adverse effects, drug interactions, ease of dosing, and applicability in patients with preexisting disease states, and especially in liver transplant recipients, are presented in this paper.
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spelling pubmed-34331272012-09-10 Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients Van Thiel, David H. George, Magdalena Moore, Christopher M. Int J Hepatol Review Article Systemic fungal infections typically occur in individuals who are seriously ill with recognized risk factors such as those frequently found in transplant recipients. Unfortunately, they are often diagnosed late, when the efficacy of the available treatments is low, often less than 50%, and the cost in terms of lives lost, hospital length of stay, and total hospital costs is substantially increased. The application of antifungal therapies associated with reported efficacy rates greater than 50% are those used prophylactically. When used prophylactically, these infections are reduced in greater than 95% of the expected cases. The choice of a prophylactic agent should be based upon its ease of administration, lack of adverse effects, reduced likelihood of potential drug interactions, and its efficacy in patients with established risk factors and comorbid disease processes that include renal, hepatic, and chronic pulmonary disease. The indications for the use of currently available antifungal agents, their adverse effects, drug interactions, ease of dosing, and applicability in patients with preexisting disease states, and especially in liver transplant recipients, are presented in this paper. Hindawi Publishing Corporation 2012 2012-08-26 /pmc/articles/PMC3433127/ /pubmed/22966464 http://dx.doi.org/10.1155/2012/106923 Text en Copyright © 2012 David H. Van Thiel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Van Thiel, David H.
George, Magdalena
Moore, Christopher M.
Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients
title Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients
title_full Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients
title_fullStr Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients
title_full_unstemmed Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients
title_short Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients
title_sort fungal infections: their diagnosis and treatment in transplant recipients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433127/
https://www.ncbi.nlm.nih.gov/pubmed/22966464
http://dx.doi.org/10.1155/2012/106923
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