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Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study

Background. Glycemic control following total pancreatectomy (TP) has been thought to be difficult to manage. Diffuse intraductal papillary mucinous neoplasm (IPMN) is a potentially curable precursor to pancreatic adenocarcinoma, best treated by TP. Objective. Compare glycemic control in patients und...

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Autores principales: Jamil, Laith H., Chindris, Ana M., Gill, Kanwar R. S., Scimeca, Daniela, Stauffer, John A., Heckman, Michael G., Meek, Shon E., Nguyen, Justin H., Asbun, Horacio J., Raimondo, Massimo, Woodward, Timothy A., Wallace, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433133/
https://www.ncbi.nlm.nih.gov/pubmed/22966212
http://dx.doi.org/10.1155/2012/381328
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author Jamil, Laith H.
Chindris, Ana M.
Gill, Kanwar R. S.
Scimeca, Daniela
Stauffer, John A.
Heckman, Michael G.
Meek, Shon E.
Nguyen, Justin H.
Asbun, Horacio J.
Raimondo, Massimo
Woodward, Timothy A.
Wallace, Michael B.
author_facet Jamil, Laith H.
Chindris, Ana M.
Gill, Kanwar R. S.
Scimeca, Daniela
Stauffer, John A.
Heckman, Michael G.
Meek, Shon E.
Nguyen, Justin H.
Asbun, Horacio J.
Raimondo, Massimo
Woodward, Timothy A.
Wallace, Michael B.
author_sort Jamil, Laith H.
collection PubMed
description Background. Glycemic control following total pancreatectomy (TP) has been thought to be difficult to manage. Diffuse intraductal papillary mucinous neoplasm (IPMN) is a potentially curable precursor to pancreatic adenocarcinoma, best treated by TP. Objective. Compare glycemic control in patients undergoing TP for IPMN to patients with type 1 diabetes mellitus (DM). Design/Setting. Retrospective cohort. Outcome Measure. Hemoglobin A1C(HbA1C) at 6, 12, 18, and 24 months after TP. In the control group, baseline was defined as 6 months prior to the first HbA1c measure. Results. Mean HgbA1C at each point of interest was similar between TP and type I DM patients (6 months (7.5% versus 7.7%, P = 0.52), 12 months (7.3% versus 8.0%, P = 0.081), 18 months (7.7% and 7.6%, P = 0.64), and at 24 months (7.3% versus 7.8%, P = 0.10)). Seven TP patients (50%) experienced a hypoglycemic event compared to 65 type 1 DM patients (65%, P = 0.38). Limitations. Small number of TP patients, retrospective design, lack of long-termfollowup. Conclusion. This suggests that glycemic control following TP for IPMNcan be well managed, similar to type 1 DM patients. Fear of DM following TP for IPMN should not preclude surgery when TP is indicated.
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spelling pubmed-34331332012-09-10 Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study Jamil, Laith H. Chindris, Ana M. Gill, Kanwar R. S. Scimeca, Daniela Stauffer, John A. Heckman, Michael G. Meek, Shon E. Nguyen, Justin H. Asbun, Horacio J. Raimondo, Massimo Woodward, Timothy A. Wallace, Michael B. HPB Surg Research Article Background. Glycemic control following total pancreatectomy (TP) has been thought to be difficult to manage. Diffuse intraductal papillary mucinous neoplasm (IPMN) is a potentially curable precursor to pancreatic adenocarcinoma, best treated by TP. Objective. Compare glycemic control in patients undergoing TP for IPMN to patients with type 1 diabetes mellitus (DM). Design/Setting. Retrospective cohort. Outcome Measure. Hemoglobin A1C(HbA1C) at 6, 12, 18, and 24 months after TP. In the control group, baseline was defined as 6 months prior to the first HbA1c measure. Results. Mean HgbA1C at each point of interest was similar between TP and type I DM patients (6 months (7.5% versus 7.7%, P = 0.52), 12 months (7.3% versus 8.0%, P = 0.081), 18 months (7.7% and 7.6%, P = 0.64), and at 24 months (7.3% versus 7.8%, P = 0.10)). Seven TP patients (50%) experienced a hypoglycemic event compared to 65 type 1 DM patients (65%, P = 0.38). Limitations. Small number of TP patients, retrospective design, lack of long-termfollowup. Conclusion. This suggests that glycemic control following TP for IPMNcan be well managed, similar to type 1 DM patients. Fear of DM following TP for IPMN should not preclude surgery when TP is indicated. Hindawi Publishing Corporation 2012 2012-08-26 /pmc/articles/PMC3433133/ /pubmed/22966212 http://dx.doi.org/10.1155/2012/381328 Text en Copyright © 2012 Laith H. Jamil et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jamil, Laith H.
Chindris, Ana M.
Gill, Kanwar R. S.
Scimeca, Daniela
Stauffer, John A.
Heckman, Michael G.
Meek, Shon E.
Nguyen, Justin H.
Asbun, Horacio J.
Raimondo, Massimo
Woodward, Timothy A.
Wallace, Michael B.
Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study
title Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study
title_full Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study
title_fullStr Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study
title_full_unstemmed Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study
title_short Glycemic Control after Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm: An Exploratory Study
title_sort glycemic control after total pancreatectomy for intraductal papillary mucinous neoplasm: an exploratory study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433133/
https://www.ncbi.nlm.nih.gov/pubmed/22966212
http://dx.doi.org/10.1155/2012/381328
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