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Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus
BACKGROUND: Mosquito-borne viruses are transmitted to human hosts via blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infections, it is important to understand how they modulate host-seeking behavior. D...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433307/ https://www.ncbi.nlm.nih.gov/pubmed/22574823 http://dx.doi.org/10.1186/1756-3305-5-92 |
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author | Fukumitsu, Yuki Irie, Keiichi Satho, Tomomitsu Aonuma, Hitoshi Dieng, Hamady Ahmad, Abu Hassan Nakashima, Yukihiko Mishima, Kenichi Kashige, Nobuhiro Miake, Fumio |
author_facet | Fukumitsu, Yuki Irie, Keiichi Satho, Tomomitsu Aonuma, Hitoshi Dieng, Hamady Ahmad, Abu Hassan Nakashima, Yukihiko Mishima, Kenichi Kashige, Nobuhiro Miake, Fumio |
author_sort | Fukumitsu, Yuki |
collection | PubMed |
description | BACKGROUND: Mosquito-borne viruses are transmitted to human hosts via blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infections, it is important to understand how they modulate host-seeking behavior. Dopamine (DA) in the central nervous system acts as a neuromediator that regulates a variety of behaviors in insects. In female mosquitoes, host-seeking behavior increases when DA levels in the head decline after emergence. However, it remains unclear whether DA directly modulates host-seeking behavior in female mosquitoes. The aim of this study was to examine whether changes in DA levels in the head affects host-seeking activity in the adult female mosquito Aedes albopictus (Ae. albopictus). FINDINGS: We compared host-seeking behavior in one group of emerging female adults treated with l-β-3,4-dihydroxyphenylalanine (l-DOPA), the precursor of DA, (l-DOPA group), with that in an untreated control (control group) after confirming elevation of head DA in l-DOPA group by using high-performance liquid chromatography. The content of head DA in l-DOPA group significantly remained higher than that in controls on all days examined. The host-seeking activity in the control group showed a gradual increase over the 6-day experimental period. In contrast, there was no such increase in the host-seeking activity in the l-DOPA group. Therefore, the host-seeking activity of l-DOPA group was significantly lower than that of the controls between day 3 and 6 post-emergence. CONCLUSION: Our results indicate that elevation of DA level reduces host-seeking activity in adult female mosquito Ae. albopictus. |
format | Online Article Text |
id | pubmed-3433307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34333072012-09-05 Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus Fukumitsu, Yuki Irie, Keiichi Satho, Tomomitsu Aonuma, Hitoshi Dieng, Hamady Ahmad, Abu Hassan Nakashima, Yukihiko Mishima, Kenichi Kashige, Nobuhiro Miake, Fumio Parasit Vectors Short Report BACKGROUND: Mosquito-borne viruses are transmitted to human hosts via blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infections, it is important to understand how they modulate host-seeking behavior. Dopamine (DA) in the central nervous system acts as a neuromediator that regulates a variety of behaviors in insects. In female mosquitoes, host-seeking behavior increases when DA levels in the head decline after emergence. However, it remains unclear whether DA directly modulates host-seeking behavior in female mosquitoes. The aim of this study was to examine whether changes in DA levels in the head affects host-seeking activity in the adult female mosquito Aedes albopictus (Ae. albopictus). FINDINGS: We compared host-seeking behavior in one group of emerging female adults treated with l-β-3,4-dihydroxyphenylalanine (l-DOPA), the precursor of DA, (l-DOPA group), with that in an untreated control (control group) after confirming elevation of head DA in l-DOPA group by using high-performance liquid chromatography. The content of head DA in l-DOPA group significantly remained higher than that in controls on all days examined. The host-seeking activity in the control group showed a gradual increase over the 6-day experimental period. In contrast, there was no such increase in the host-seeking activity in the l-DOPA group. Therefore, the host-seeking activity of l-DOPA group was significantly lower than that of the controls between day 3 and 6 post-emergence. CONCLUSION: Our results indicate that elevation of DA level reduces host-seeking activity in adult female mosquito Ae. albopictus. BioMed Central 2012-05-10 /pmc/articles/PMC3433307/ /pubmed/22574823 http://dx.doi.org/10.1186/1756-3305-5-92 Text en Copyright ©2012 Fukumitsu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Fukumitsu, Yuki Irie, Keiichi Satho, Tomomitsu Aonuma, Hitoshi Dieng, Hamady Ahmad, Abu Hassan Nakashima, Yukihiko Mishima, Kenichi Kashige, Nobuhiro Miake, Fumio Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus |
title | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus |
title_full | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus |
title_fullStr | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus |
title_full_unstemmed | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus |
title_short | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus |
title_sort | elevation of dopamine level reduces host-seeking activity in the adult female mosquito aedes albopictus |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433307/ https://www.ncbi.nlm.nih.gov/pubmed/22574823 http://dx.doi.org/10.1186/1756-3305-5-92 |
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