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Vitamin B(12) deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse

BACKGROUND: DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B(12) and folate pathways are involved in the production of S-Adenosylmethionine, the universal methyl donor. FINDINGS: Brain vitamin B(12) concentration and gl...

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Detalles Bibliográficos
Autores principales:	Fernàndez-Roig, Sílvia, Lai, Shao-Chiang, Murphy, Michelle M, Fernandez-Ballart, Joan, Quadros, Edward V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433370/ https://www.ncbi.nlm.nih.gov/pubmed/22607050 http://dx.doi.org/10.1186/1743-7075-9-41

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