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Comprehensive Binary Interaction Mapping of SH2 Domains via Fluorescence Polarization Reveals Novel Functional Diversification of ErbB Receptors

First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies. Here, we developed a large-scale fluorescence polarization (FP) methodology that was able to characterize inte...

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Detalles Bibliográficos
Autores principales:	Hause, Ronald J., Leung, Kin K., Barkinge, John L., Ciaccio, Mark F., Chuu, Chih-pin, Jones, Richard B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433420/ https://www.ncbi.nlm.nih.gov/pubmed/22973453 http://dx.doi.org/10.1371/journal.pone.0044471

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