Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations

BACKGROUND: Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorders. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant inherited ion channel disorder predominantly caused by mutations in the cardiac ryanodine receptor (RyR2). In...

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Detalles Bibliográficos
Autores principales: Kujala, Kirsi, Paavola, Jere, Lahti, Anna, Larsson, Kim, Pekkanen-Mattila, Mari, Viitasalo, Matti, Lahtinen, Annukka M., Toivonen, Lauri, Kontula, Kimmo, Swan, Heikki, Laine, Mika, Silvennoinen, Olli, Aalto-Setälä, Katriina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433449/
https://www.ncbi.nlm.nih.gov/pubmed/22962621
http://dx.doi.org/10.1371/journal.pone.0044660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433449/
https://www.ncbi.nlm.nih.gov/pubmed/22962621
http://dx.doi.org/10.1371/journal.pone.0044660

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