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Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse

Pharmacological agents, such as bezafibrate, that activate peroxisome proliferator-activated receptors (PPARs) and PPAR γ coactivator-1α (PGC-1α) pathways have been shown to improve mitochondrial function and energy metabolism. The mitochondrial DNA (mtDNA) mutator mouse is a mouse model of aging th...

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Detalles Bibliográficos
Autores principales:	Dillon, Lloye M., Hida, Aline, Garcia, Sofia, Prolla, Tomas A., Moraes, Carlos T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433471/ https://www.ncbi.nlm.nih.gov/pubmed/22962610 http://dx.doi.org/10.1371/journal.pone.0044335

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