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Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection
BACKGROUND: The broad applicability of RNA aptamers as cell-specific delivery tools for therapeutic reagents depends on the ability to identify aptamer sequences that selectively access the cytoplasm of distinct cell types. Towards this end, we have developed a novel approach that combines a cell-ba...
Autores principales: | Thiel, William H., Bair, Thomas, Peek, Andrew S., Liu, Xiuying, Dassie, Justin, Stockdale, Katie R., Behlke, Mark A., Miller, Francis J., Giangrande, Paloma H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433472/ https://www.ncbi.nlm.nih.gov/pubmed/22962591 http://dx.doi.org/10.1371/journal.pone.0043836 |
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