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Continuous renal replacement therapy in neonates weighing less than 3 kg

PURPOSE: Continuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical applicat...

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Autores principales: Sohn, Young Bae, Paik, Kyung Hoon, Cho, Hee Yeon, Kim, Su Jin, Park, Sung Won, Kim, Eun Sun, Chang, Yun Sil, Park, Won-Soon, Choi, Yoon-Ho, Jin, Dong-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Pediatric Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433565/
https://www.ncbi.nlm.nih.gov/pubmed/22977441
http://dx.doi.org/10.3345/kjp.2012.55.8.286
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author Sohn, Young Bae
Paik, Kyung Hoon
Cho, Hee Yeon
Kim, Su Jin
Park, Sung Won
Kim, Eun Sun
Chang, Yun Sil
Park, Won-Soon
Choi, Yoon-Ho
Jin, Dong-Kyu
author_facet Sohn, Young Bae
Paik, Kyung Hoon
Cho, Hee Yeon
Kim, Su Jin
Park, Sung Won
Kim, Eun Sun
Chang, Yun Sil
Park, Won-Soon
Choi, Yoon-Ho
Jin, Dong-Kyu
author_sort Sohn, Young Bae
collection PubMed
description PURPOSE: Continuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical application, outcome, and complications of CRRT in small neonates. METHODS: A retrospective review was performed in 8 neonatal patients who underwent at least 24 hours of pumped venovenous CRRT at the Samsung Medical Center in Seoul, Korea, between March 2007 and July 2010. Data, including demographic characteristics, diagnosis, vital signs, medications, laboratory, and CRRT parameters were recorded. RESULTS: The data of 8 patients were analyzed. At the initiation of CRRT, the median age was 5 days (corrected age, 38(+2) weeks to 23 days), and the median body weight was 2.73 kg (range, 2.60 to 2.98 kg). Sixty-two patient-days of therapy were reviewed; the median time for CRRT in each patient was 7.8 days (range, 1 to 37 days). Adverse events included electrolyte disturbances, catheter-related complications, and CRRT-related hypotension. The mean circuit functional survival was 13.9±8.6 hours. Overall, 4 patients (50%) survived; the other 4 patients, who developed multiorgan dysfunction syndrome, died. CONCLUSION: The complications of CRRT in newborns are relatively high. However, the results of this study suggest that venovenous CRRT is feasible and effective in neonates weighing less than 3 kg under elaborate supportive care. Furthermore, for using potential benefit of CRRT in neonates, efforts are required for prolonging filter survival.
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spelling pubmed-34335652012-09-13 Continuous renal replacement therapy in neonates weighing less than 3 kg Sohn, Young Bae Paik, Kyung Hoon Cho, Hee Yeon Kim, Su Jin Park, Sung Won Kim, Eun Sun Chang, Yun Sil Park, Won-Soon Choi, Yoon-Ho Jin, Dong-Kyu Korean J Pediatr Original Article PURPOSE: Continuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim of this study is to describe the clinical application, outcome, and complications of CRRT in small neonates. METHODS: A retrospective review was performed in 8 neonatal patients who underwent at least 24 hours of pumped venovenous CRRT at the Samsung Medical Center in Seoul, Korea, between March 2007 and July 2010. Data, including demographic characteristics, diagnosis, vital signs, medications, laboratory, and CRRT parameters were recorded. RESULTS: The data of 8 patients were analyzed. At the initiation of CRRT, the median age was 5 days (corrected age, 38(+2) weeks to 23 days), and the median body weight was 2.73 kg (range, 2.60 to 2.98 kg). Sixty-two patient-days of therapy were reviewed; the median time for CRRT in each patient was 7.8 days (range, 1 to 37 days). Adverse events included electrolyte disturbances, catheter-related complications, and CRRT-related hypotension. The mean circuit functional survival was 13.9±8.6 hours. Overall, 4 patients (50%) survived; the other 4 patients, who developed multiorgan dysfunction syndrome, died. CONCLUSION: The complications of CRRT in newborns are relatively high. However, the results of this study suggest that venovenous CRRT is feasible and effective in neonates weighing less than 3 kg under elaborate supportive care. Furthermore, for using potential benefit of CRRT in neonates, efforts are required for prolonging filter survival. The Korean Pediatric Society 2012-08 2012-08-23 /pmc/articles/PMC3433565/ /pubmed/22977441 http://dx.doi.org/10.3345/kjp.2012.55.8.286 Text en Copyright © 2012 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sohn, Young Bae
Paik, Kyung Hoon
Cho, Hee Yeon
Kim, Su Jin
Park, Sung Won
Kim, Eun Sun
Chang, Yun Sil
Park, Won-Soon
Choi, Yoon-Ho
Jin, Dong-Kyu
Continuous renal replacement therapy in neonates weighing less than 3 kg
title Continuous renal replacement therapy in neonates weighing less than 3 kg
title_full Continuous renal replacement therapy in neonates weighing less than 3 kg
title_fullStr Continuous renal replacement therapy in neonates weighing less than 3 kg
title_full_unstemmed Continuous renal replacement therapy in neonates weighing less than 3 kg
title_short Continuous renal replacement therapy in neonates weighing less than 3 kg
title_sort continuous renal replacement therapy in neonates weighing less than 3 kg
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433565/
https://www.ncbi.nlm.nih.gov/pubmed/22977441
http://dx.doi.org/10.3345/kjp.2012.55.8.286
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