Small molecule-induced DNA damage identifies alternative DNA structures in human genes

Guanine-rich DNA sequences that can adopt non-Watson-Crick structures in vitro are prevalent in the human genome. Whether such structures normally exist in mammalian cells has, however, been the subject of active research for decades. Here, we show that the G-quadruplex interacting drug pyridostatin...

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Detalles Bibliográficos
Autores principales: Rodriguez, Raphaël, Miller, Kyle M., Forment, Josep V., Bradshaw, Charles R., Nikan, Mehran, Britton, Sébastien, Oelschlaegel, Tobias, Xhemalce, Blerta, Balasubramanian, Shankar, Jackson, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433707/
https://www.ncbi.nlm.nih.gov/pubmed/22306580
http://dx.doi.org/10.1038/nchembio.780

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