Cargando…

Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus

Most HIV transmission in women occurs through the cervicovaginal mucosa, which is coated by a bacterial biofilm including Lactobacillus. This commensal bacterium plays a role in maintaining healthy mucosa and can be genetically engineered to produce anti-viral peptides. Here, we report a 63% reducti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lagenaur, Laurel A, Sanders-Beer, Brigitte E, Brichacek, Beda, Pal, Ranajit, Liu, Xiaowen, Liu, Yang, Yu, Rosa, Venzon, David, Lee, Peter P, Hamer, Dean H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433722/ https://www.ncbi.nlm.nih.gov/pubmed/21734653 http://dx.doi.org/10.1038/mi.2011.30

Ejemplares similares

In Vivo Evaluation of Safety and Toxicity of a Lactobacillus jensenii Producing Modified Cyanovirin-N in a Rhesus Macaque Vaginal Challenge Model
por: Brichacek, Beda, et al.
Publicado: (2013)

Prevention of Vaginal SHIV Transmission in Macaques by a Coitally-Dependent Truvada Regimen
por: Radzio, Jessica, et al.
Publicado: (2012)

Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques
por: Sui, Yongjun, et al.
Publicado: (2018)

Robust Vaginal Colonization of Macaques with a Novel Vaginally Disintegrating Tablet Containing a Live Biotherapeutic Product to Prevent HIV Infection in Women
por: Lagenaur, Laurel A., et al.
Publicado: (2015)

Expression of Human Immunodeficiency Virus Type 1 Neutralizing Antibody Fragments Using Human Vaginal Lactobacillus
por: Marcobal, Angela, et al.
Publicado: (2016)

SHIV-162P3 Infection of Rhesus Macaques Given Maraviroc Gel Vaginally Does Not Involve Resistant Viruses
por: Tsibris, Athe M. N., et al.
Publicado: (2011)

A MIV-150/Zinc Acetate Gel Inhibits SHIV-RT Infection in Macaque Vaginal Explants
por: Barnable, Patrick, et al.
Publicado: (2014)

The Vaginal Microbiome of Nonhuman Primates Can Be Only Transiently Altered to Become Lactobacillus Dominant without Reducing Inflammation
por: Langner, Charlotte A., et al.
Publicado: (2021)

An Antiretroviral/Zinc Combination Gel Provides 24 Hours of Complete Protection against Vaginal SHIV Infection in Macaques
por: Kenney, Jessica, et al.
Publicado: (2011)

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques
por: Calenda, Giulia, et al.
Publicado: (2019)

Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir
por: García-Lerma, J. Gerardo, et al.
Publicado: (2008)

Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques
por: Dobard, Charles W, et al.
Publicado: (2015)

A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques
por: Nzounza, Patrycja, et al.
Publicado: (2021)

Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure
por: Suphaphiphat, Karunasinee, et al.
Publicado: (2023)

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV(162P3) in Cynomolgus Macaques
por: Dereuddre-Bosquet, Nathalie, et al.
Publicado: (2012)

Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
por: Chang, Xiao L., et al.
Publicado: (2021)

Antibody mediated protection of immunized macaques against pathogenic SHIV challenge
por: Srivastava, Indresh K, et al.
Publicado: (2006)

HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model
por: Saba, Elisa, et al.
Publicado: (2010)

The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques
por: Wang, Rui-Rui, et al.
Publicado: (2015)

Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques
por: Liu, JB, et al.
Publicado: (2018)

Altered gene expression in asymptomatic SHIV-infected rhesus macaques (Macacca mulatta)
por: Carroll, Erica E, et al.
Publicado: (2006)

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy
por: Shao, Wei, et al.
Publicado: (2009)

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV
por: Marshall, Vickie A., et al.
Publicado: (2018)

CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
por: Fan, Jin, et al.
Publicado: (2019)

Long-acting capsid inhibitor protects macaques from repeat SHIV challenges
por: Vidal, Samuel J., et al.
Publicado: (2021)

Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques
por: Rahman, Mohammad Arif, et al.
Publicado: (2023)

Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques
por: Dobard, Charles W., et al.
Publicado: (2022)

Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose
por: Sholukh, Anton M, et al.
Publicado: (2014)

Limited SHIV env diversification in macaques failing oral antiretroviral pre-exposure prophylaxis
por: Zheng, Qi, et al.
Publicado: (2012)

Longitudinal analysis of the lung microbiota of cynomolgous macaques during long-term SHIV infection
por: Morris, Alison, et al.
Publicado: (2016)

Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques
por: Zhang, Gao-Hong, et al.
Publicado: (2016)

Expression of pIgR in the tracheal mucosa of SHIV/SIV-infected rhesus macaques
por: Li, Dong, et al.
Publicado: (2017)

Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia
por: Nishimura, Yoshiaki, et al.
Publicado: (2020)

Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies
por: Hora, Bhavna, et al.
Publicado: (2023)

Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques
por: Walker-Sperling, Victoria E. K., et al.
Publicado: (2022)

Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
por: Cadena, Anthony M., et al.
Publicado: (2021)

Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4(+) T Cells
por: Obregon-Perko, Veronica, et al.
Publicado: (2020)

Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques
por: Wen, Jing, et al.
Publicado: (2021)

Publisher Correction: Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques
por: Rahman, Mohammad Arif, et al.
Publicado: (2023)

Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
por: Ng, Cherie T., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_pktncn8rve8v1bau5mbuc78vh5