Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is also manifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But can gerossuppression suppress tumors?

Detalles Bibliográficos
Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433931/
https://www.ncbi.nlm.nih.gov/pubmed/22869016
_version_ 1782242363554398208
author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is also manifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But can gerossuppression suppress tumors?
format Online
Article
Text
id pubmed-3433931
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-34339312012-09-11 Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression? Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is also manifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But can gerossuppression suppress tumors? Impact Journals LLC 2012-07-31 /pmc/articles/PMC3433931/ /pubmed/22869016 Text en Copyright: © 2012 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
Blagosklonny, Mikhail V.
Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
title Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
title_full Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
title_fullStr Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
title_full_unstemmed Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
title_short Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
title_sort tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433931/
https://www.ncbi.nlm.nih.gov/pubmed/22869016
work_keys_str_mv AT blagosklonnymikhailv tumorsuppressionbyp53withoutapoptosisandsenescenceconundrumorrapaloglikegerosuppression

Ejemplares similares