Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding

BACKGROUND: S100 proteins are a family of small, EF-hand containing calcium-binding signaling proteins that are implicated in many cancers. While the majority of human S100 proteins share 25-65% sequence similarity, S100A7 and its recently identified paralog, S100A15, display 93% sequence identity....

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Detalles Bibliográficos
Autores principales: Murray, Jill I, Tonkin, Michelle L, Whiting, Amanda L, Peng, Fangni, Farnell, Benjamin, Cullen, Jay T, Hof, Fraser, Boulanger, Martin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434032/
https://www.ncbi.nlm.nih.gov/pubmed/22747601
http://dx.doi.org/10.1186/1472-6807-12-16

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