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Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases

BACKGROUND: Recently published results of quality of life (QoL) studies indicated different outcomes of palliative radiotherapy for brain metastases. This prospective multi-center QoL study of patients with brain metastases was designed to investigate which QoL domains improve or worsen after pallia...

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Autores principales: Steinmann, Diana, Paelecke-Habermann, Yvonne, Geinitz, Hans, Aschoff, Raimund, Bayerl, Anja, Bölling, Tobias, Bosch, Elisabeth, Bruns, Frank, Eichenseder-Seiss, Ute, Gerstein, Johanna, Gharbi, Nadine, Hagg, Juliane, Hipp, Matthias, Kleff, Irmgard, Müller, Axel, Schäfer, Christof, Schleicher, Ursula, Sehlen, Susanne, Theodorou, Marilena, Wypior, Hans-Joachim, Zehentmayr, Franz, van Oorschot, Birgitt, Vordermark, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434068/
https://www.ncbi.nlm.nih.gov/pubmed/22780988
http://dx.doi.org/10.1186/1471-2407-12-283
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author Steinmann, Diana
Paelecke-Habermann, Yvonne
Geinitz, Hans
Aschoff, Raimund
Bayerl, Anja
Bölling, Tobias
Bosch, Elisabeth
Bruns, Frank
Eichenseder-Seiss, Ute
Gerstein, Johanna
Gharbi, Nadine
Hagg, Juliane
Hipp, Matthias
Kleff, Irmgard
Müller, Axel
Schäfer, Christof
Schleicher, Ursula
Sehlen, Susanne
Theodorou, Marilena
Wypior, Hans-Joachim
Zehentmayr, Franz
van Oorschot, Birgitt
Vordermark, Dirk
author_facet Steinmann, Diana
Paelecke-Habermann, Yvonne
Geinitz, Hans
Aschoff, Raimund
Bayerl, Anja
Bölling, Tobias
Bosch, Elisabeth
Bruns, Frank
Eichenseder-Seiss, Ute
Gerstein, Johanna
Gharbi, Nadine
Hagg, Juliane
Hipp, Matthias
Kleff, Irmgard
Müller, Axel
Schäfer, Christof
Schleicher, Ursula
Sehlen, Susanne
Theodorou, Marilena
Wypior, Hans-Joachim
Zehentmayr, Franz
van Oorschot, Birgitt
Vordermark, Dirk
author_sort Steinmann, Diana
collection PubMed
description BACKGROUND: Recently published results of quality of life (QoL) studies indicated different outcomes of palliative radiotherapy for brain metastases. This prospective multi-center QoL study of patients with brain metastases was designed to investigate which QoL domains improve or worsen after palliative radiotherapy and which might provide prognostic information. METHODS: From 01/2007-01/2009, n=151 patients with previously untreated brain metastases were recruited at 14 centers in Germany and Austria. Most patients (82 %) received whole-brain radiotherapy. QoL was measured with the EORTC-QLQ-C15-PAL and brain module BN20 before the start of radiotherapy and after 3 months. RESULTS: At 3 months, 88/142 (62 %) survived. Nine patients were not able to be followed up. 62 patients (70.5 % of 3-month survivors) completed the second set of questionnaires. Three months after the start of radiotherapy QoL deteriorated significantly in the areas of global QoL, physical function, fatigue, nausea, pain, appetite loss, hair loss, drowsiness, motor dysfunction, communication deficit and weakness of legs. Although the use of corticosteroid at 3 months could be reduced compared to pre-treatment (63 % vs. 37 %), the score for headaches remained stable. Initial QoL at the start of treatment was better in those alive than in those deceased at 3 months, significantly for physical function, motor dysfunction and the symptom scales fatigue, pain, appetite loss and weakness of legs. In a multivariate model, lower Karnofsky performance score, higher age and higher pain ratings before radiotherapy were prognostic of 3-month survival. CONCLUSIONS: Moderate deterioration in several QoL domains was predominantly observed three months after start of palliative radiotherapy for brain metastases. Future studies will need to address the individual subjective benefit or burden from such treatment. Baseline QoL scores before palliative radiotherapy for brain metastases may contain prognostic information.
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spelling pubmed-34340682012-09-06 Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases Steinmann, Diana Paelecke-Habermann, Yvonne Geinitz, Hans Aschoff, Raimund Bayerl, Anja Bölling, Tobias Bosch, Elisabeth Bruns, Frank Eichenseder-Seiss, Ute Gerstein, Johanna Gharbi, Nadine Hagg, Juliane Hipp, Matthias Kleff, Irmgard Müller, Axel Schäfer, Christof Schleicher, Ursula Sehlen, Susanne Theodorou, Marilena Wypior, Hans-Joachim Zehentmayr, Franz van Oorschot, Birgitt Vordermark, Dirk BMC Cancer Research Article BACKGROUND: Recently published results of quality of life (QoL) studies indicated different outcomes of palliative radiotherapy for brain metastases. This prospective multi-center QoL study of patients with brain metastases was designed to investigate which QoL domains improve or worsen after palliative radiotherapy and which might provide prognostic information. METHODS: From 01/2007-01/2009, n=151 patients with previously untreated brain metastases were recruited at 14 centers in Germany and Austria. Most patients (82 %) received whole-brain radiotherapy. QoL was measured with the EORTC-QLQ-C15-PAL and brain module BN20 before the start of radiotherapy and after 3 months. RESULTS: At 3 months, 88/142 (62 %) survived. Nine patients were not able to be followed up. 62 patients (70.5 % of 3-month survivors) completed the second set of questionnaires. Three months after the start of radiotherapy QoL deteriorated significantly in the areas of global QoL, physical function, fatigue, nausea, pain, appetite loss, hair loss, drowsiness, motor dysfunction, communication deficit and weakness of legs. Although the use of corticosteroid at 3 months could be reduced compared to pre-treatment (63 % vs. 37 %), the score for headaches remained stable. Initial QoL at the start of treatment was better in those alive than in those deceased at 3 months, significantly for physical function, motor dysfunction and the symptom scales fatigue, pain, appetite loss and weakness of legs. In a multivariate model, lower Karnofsky performance score, higher age and higher pain ratings before radiotherapy were prognostic of 3-month survival. CONCLUSIONS: Moderate deterioration in several QoL domains was predominantly observed three months after start of palliative radiotherapy for brain metastases. Future studies will need to address the individual subjective benefit or burden from such treatment. Baseline QoL scores before palliative radiotherapy for brain metastases may contain prognostic information. BioMed Central 2012-07-10 /pmc/articles/PMC3434068/ /pubmed/22780988 http://dx.doi.org/10.1186/1471-2407-12-283 Text en Copyright ©2012 Steinmann et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Steinmann, Diana
Paelecke-Habermann, Yvonne
Geinitz, Hans
Aschoff, Raimund
Bayerl, Anja
Bölling, Tobias
Bosch, Elisabeth
Bruns, Frank
Eichenseder-Seiss, Ute
Gerstein, Johanna
Gharbi, Nadine
Hagg, Juliane
Hipp, Matthias
Kleff, Irmgard
Müller, Axel
Schäfer, Christof
Schleicher, Ursula
Sehlen, Susanne
Theodorou, Marilena
Wypior, Hans-Joachim
Zehentmayr, Franz
van Oorschot, Birgitt
Vordermark, Dirk
Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases
title Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases
title_full Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases
title_fullStr Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases
title_full_unstemmed Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases
title_short Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases
title_sort prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434068/
https://www.ncbi.nlm.nih.gov/pubmed/22780988
http://dx.doi.org/10.1186/1471-2407-12-283
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