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Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels
Human ether-a-go-go–related gene (hERG) potassium channels exhibit unique gating kinetics characterized by unusually slow activation and deactivation. The N terminus of the channel, which contains an amphipathic helix and an unstructured tail, has been shown to be involved in regulation of this slow...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434099/ https://www.ncbi.nlm.nih.gov/pubmed/22891279 http://dx.doi.org/10.1085/jgp.201110761 |