Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines

Downregulation of microRNAs (miRNAs) at the 14q32 locus stabilizes the expression of cMYC, thus significantly contributing to osteosarcoma (OS) pathobiology. Here, we show that downregulation of 14q32 miRNAs is epigenetically regulated. The predicted promoter regions of miRNA clusters at 14q32 locus...

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Detalles Bibliográficos
Autores principales: Thayanithy, Venugopal, Park, ChangWon, Sarver, Aaron L., Kartha, Reena V., Korpela, Derek M., Graef, Ashley J., Steer, Clifford J., Modiano, Jaime F., Subramanian, Subbaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434163/
https://www.ncbi.nlm.nih.gov/pubmed/22957032
http://dx.doi.org/10.1371/journal.pone.0043720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434163/
https://www.ncbi.nlm.nih.gov/pubmed/22957032
http://dx.doi.org/10.1371/journal.pone.0043720

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