Cargando…

Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens

The purposes of the present study were to evaluate the hepatocarcinogenicity of concurrent treatment of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and diethylnitrosamine (DEN) in rats and to determine whether no effect levels of combinations of these two different structural categories of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Min, Kakehashi, Anna, Yamano, Shotaro, Tamano, Seiko, Shirai, Tomoyuki, Wanibuchi, Hideki, Fukushima, Shoji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japanese Society of Toxicologic Pathology 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434336/ https://www.ncbi.nlm.nih.gov/pubmed/22988339 http://dx.doi.org/10.1293/tox.25.209

Ejemplares similares

Lack of a Dose‐response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline or N‐Nitrosodiethylamine
por: Fukushima, Shoji, et al.
Publicado: (2002)

Lack of Carcinogenicity of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in Cynomolgus Monkeys
por: Ogawa, Kumiko, et al.
Publicado: (1999)

Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens
por: Fukushima, Shoji, et al.
Publicado: (2018)

Effects of Chlorophyll a and b in Reducing Genotoxicity of 2-Amino-3,8-dimethylimidazo[4,5-F]quinoxaline (MeIQx)
por: Kocaoğlu Cenkci, Serap, et al.
Publicado: (2022)

Oxidative Stress in the Carcinogenicity of Chemical Carcinogens
por: Kakehashi, Anna, et al.
Publicado: (2013)

Formation and Removal of DNA Adducts in the Liver of Rats Chronically Fed the Food‐borne Carcinogen, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline
por: Hirose, Misako, et al.
Publicado: (1995)

Dose‐dependent Induction of 8‐Hydroxyguanine and Preneoplastic Foci in Rat Liver by a Food‐derived Carcinogen, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline, at Low Dose Levels
por: Kato, Toshio, et al.
Publicado: (1996)

Thresholds of Genotoxic and Non-Genotoxic Carcinogens
por: Nohmi, Takehiko
Publicado: (2018)

Metabolism of the food-borne carcinogens 2-amino-3-methylimidazo-[4,5-f]quinoline and 2-amino-3,8- dimethylimidazo[4,5-f]-quinoxaline in the rat as a model for human biomonitoring.
por: Turesky, R J, et al.
Publicado: (1993)

Inhibition of 2‐Amino‐3, 8‐dimethylimidazo[4,5‐f]quinoxaline‐mediated DNA‐adduct Formation by Chlorophyllin in Drosophila
por: Sugiyama, Chitose, et al.
Publicado: (1996)

Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline
por: Sone, Hideko, et al.
Publicado: (1996)

Mechanism of Oxidative DNA Damage Induced by a Heterocyclic Amine, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline
por: Murata, Mariko, et al.
Publicado: (1999)

Identification of consensus biomarkers for predicting non-genotoxic hepatocarcinogens
por: Huang, Shan-Han, et al.
Publicado: (2017)

Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay
por: Ishii, Naomi, et al.
Publicado: (2016)

DNA Adducts Formed by 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline in Rat Liver: Dose‐Response on Chronic Administration
por: Yamashita, Katsumi, et al.
Publicado: (1990)

Identification of Time-Invariant Biomarkers for Non-Genotoxic Hepatocarcinogen Assessment
por: Huang, Shan-Han, et al.
Publicado: (2020)

Distinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis
por: Lee, Seul Ji, et al.
Publicado: (2013)

Using FFPE RNA-Seq with 12 marker genes to evaluate genotoxic and non-genotoxic rat hepatocarcinogens
por: Furihata, Chie, et al.
Publicado: (2020)

Formation of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline‐ and 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline‐sulfamates by cDNA‐expressed Mammalian Phenol Sulfotransferases
por: Ozawa, Shogo, et al.
Publicado: (1995)

Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens
por: Batke, Monika, et al.
Publicado: (2021)

Lack of Carcinogenicity of Quercetin in F344/DuCrj Rats
por: Ito, Nobuyuki, et al.
Publicado: (1989)

Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells
por: Ito, Yuko, et al.
Publicado: (2019)

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin
Publicado: (1994)

Enhancement by Cigarette Smoke Exposure of 2‐Amino‐3,8‐dimethylimidazo[4,5‐ f]quinoxaline‐induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
por: Nishikawa, Akiyoshi, et al.
Publicado: (2002)

Effect of Route of Administration on the Carcinogenic Action of Diethylnitrosamine (N-Nitrosodiethylamine)
por: Herrold, Katherine McD.
Publicado: (1964)

Assessment of Systemic Toxicity, Genotoxicity, and Early Phase Hepatocarcinogenicity of Iron (III)-Tannic Acid Nanoparticles in Rats
por: Hlaing, Chi Be, et al.
Publicado: (2022)

Inorganic Alkalizers and Acidifiers under Conditions of High Urinary Na(+) or K(+) on Cell Proliferation and Two‐stage Carcinogenesis in the Rat Bladder
por: Shibata, Masa‐Aki, et al.
Publicado: (1992)

Evaluation of the Modifying Effect of Inhalation of Mainstream Cigarette Smoke on Mouse Bladder Carcinogenesis
por: Kato, Minoru, et al.
Publicado: (2013)

Carcinogens in Rat Milk: Transfer of Ingested Diethylnitrosamine into Milk by Lactating Rats
por: Schoental, R., et al.
Publicado: (1974)

Time‐ and Dose‐dependent Induction of Invasive Urinary Bladder Cancers by N‐Ethyl‐N‐(4‐hydroxybutyl)nitrosamine in B6C3F(1) Mice
por: Tamano, Seiko, et al.
Publicado: (1991)

Are genotoxic carcinogens more potent than nongenotoxic carcinogens?
por: Parodi, S, et al.
Publicado: (1991)

Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats
por: Doi, Yuko, et al.
Publicado: (2011)

Cyto-Genotoxic and Transcriptomic Alterations in Human Liver Cells by Tris (2-Ethylhexyl) Phosphate (TEHP): A Putative Hepatocarcinogen
por: Saquib, Quaiser, et al.
Publicado: (2022)

Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis
por: Ishii, Naomi, et al.
Publicado: (2011)

Down‐regulation of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx)‐induced CYP1A2 Expression Is Associated with Bovine Lactoferrin Inhibition of MeIQx‐induced Liver and Colon Carcinogenesis in Rats
por: Fujita, Ken‐ichi, et al.
Publicado: (2002)

Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas
por: Kakehashi, Anna, et al.
Publicado: (2009)

Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine.
por: Reznik, G., et al.
Publicado: (1976)

Mequindox Induced Genotoxicity and Carcinogenicity in Mice
por: Liu, Qianying, et al.
Publicado: (2018)

Thirdhand smoke: Genotoxicity and carcinogenic potential
por: Hang, Bo, et al.
Publicado: (2019)

Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy
por: Nakatani, Shinya, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_c1ug3the4dk97a8ck57654l5vm