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Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer

Introduction. Endocrine therapy (ET) is an integral part of breast cancer (BC) treatment with surgical resection remaining the cornerstone of curative treatment. The objective of this study is to compare the survival of elderly postmenopausal women with hormone receptor-positive early-stage BC treat...

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Autores principales: Nguyen, Olivier, Sideris, Lucas, Drolet, Pierre, Gagnon, Marie-Claude, Leblanc, Guy, Leclerc, Yves E., Mitchell, Andrew, Dubé, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434381/
https://www.ncbi.nlm.nih.gov/pubmed/22970358
http://dx.doi.org/10.1155/2012/180574
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author Nguyen, Olivier
Sideris, Lucas
Drolet, Pierre
Gagnon, Marie-Claude
Leblanc, Guy
Leclerc, Yves E.
Mitchell, Andrew
Dubé, Pierre
author_facet Nguyen, Olivier
Sideris, Lucas
Drolet, Pierre
Gagnon, Marie-Claude
Leblanc, Guy
Leclerc, Yves E.
Mitchell, Andrew
Dubé, Pierre
author_sort Nguyen, Olivier
collection PubMed
description Introduction. Endocrine therapy (ET) is an integral part of breast cancer (BC) treatment with surgical resection remaining the cornerstone of curative treatment. The objective of this study is to compare the survival of elderly postmenopausal women with hormone receptor-positive early-stage BC treated with ET alone, without radiation or chemotherapy, versus ET plus surgery. Materials and Methods. This is a retrospective study based on a prospective database. The medical records of postmenopausal BC patients referred to the surgical oncology service of two hospitals during an 8-year period were reviewed. All patients were to receive ET for a minimum of four months before undergoing any surgery. Results. Fifty-one patients were included and divided in two groups, ET alone and ET plus surgery. At last follow-up in exclusive ET patients (n = 28), 39% had stable disease or complete response, 22% had progressive disease, of which 18% died of breast cancer, and 39% died of other causes. In surgical patients (n = 23), 78% were disease-free, 9% died of recurrent breast cancer, and 13% died of other causes. Conclusions. These results suggest that surgical resection is beneficial in this group and should be considered, even for patients previously deemed ineligible for surgery.
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spelling pubmed-34343812012-09-11 Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer Nguyen, Olivier Sideris, Lucas Drolet, Pierre Gagnon, Marie-Claude Leblanc, Guy Leclerc, Yves E. Mitchell, Andrew Dubé, Pierre Int J Surg Oncol Clinical Study Introduction. Endocrine therapy (ET) is an integral part of breast cancer (BC) treatment with surgical resection remaining the cornerstone of curative treatment. The objective of this study is to compare the survival of elderly postmenopausal women with hormone receptor-positive early-stage BC treated with ET alone, without radiation or chemotherapy, versus ET plus surgery. Materials and Methods. This is a retrospective study based on a prospective database. The medical records of postmenopausal BC patients referred to the surgical oncology service of two hospitals during an 8-year period were reviewed. All patients were to receive ET for a minimum of four months before undergoing any surgery. Results. Fifty-one patients were included and divided in two groups, ET alone and ET plus surgery. At last follow-up in exclusive ET patients (n = 28), 39% had stable disease or complete response, 22% had progressive disease, of which 18% died of breast cancer, and 39% died of other causes. In surgical patients (n = 23), 78% were disease-free, 9% died of recurrent breast cancer, and 13% died of other causes. Conclusions. These results suggest that surgical resection is beneficial in this group and should be considered, even for patients previously deemed ineligible for surgery. Hindawi Publishing Corporation 2012 2012-08-27 /pmc/articles/PMC3434381/ /pubmed/22970358 http://dx.doi.org/10.1155/2012/180574 Text en Copyright © 2012 Olivier Nguyen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Nguyen, Olivier
Sideris, Lucas
Drolet, Pierre
Gagnon, Marie-Claude
Leblanc, Guy
Leclerc, Yves E.
Mitchell, Andrew
Dubé, Pierre
Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer
title Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer
title_full Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer
title_fullStr Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer
title_full_unstemmed Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer
title_short Surgery Should Complement Endocrine Therapy for Elderly Postmenopausal Women with Hormone Receptor-Positive Early-Stage Breast Cancer
title_sort surgery should complement endocrine therapy for elderly postmenopausal women with hormone receptor-positive early-stage breast cancer
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434381/
https://www.ncbi.nlm.nih.gov/pubmed/22970358
http://dx.doi.org/10.1155/2012/180574
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