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Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice

Pathological features of amyotrophic lateral sclerosis (ALS) include, in addition to selective motor neuron (MN) degeneration, the occurrence of protein aggregates, mitochondrial dysfunction and astrogliosis. SOD1 mutations cause rare familial forms of ALS and have provided the most widely studied a...

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Detalles Bibliográficos
Autores principales:	Yin, H Z, Nalbandian, A, Hsu, C-I, Li, S, Llewellyn, K J, Mozaffar, T, Kimonis, V E, Weiss, J H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434652/ https://www.ncbi.nlm.nih.gov/pubmed/22898872 http://dx.doi.org/10.1038/cddis.2012.115

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