Anti-apoptotic gene Bcl2 is required for stapes development and hearing

In this paper we describe novel and specific roles for the apoptotic regulators Bcl2 and Bim in hearing and stapes development. Bcl2 is anti-apoptotic while Bim is pro-apoptotic. Characterization of the auditory systems of mice deficient for these molecules revealed that Bcl2(−/−) mice suffered seve...

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Detalles Bibliográficos
Autores principales: Carpinelli, M R, Wise, A K, Arhatari, B D, Bouillet, P, Manji, S S M, Manning, M G, Cooray, A A, Burt, R A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434664/
https://www.ncbi.nlm.nih.gov/pubmed/22874999
http://dx.doi.org/10.1038/cddis.2012.100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434664/
https://www.ncbi.nlm.nih.gov/pubmed/22874999
http://dx.doi.org/10.1038/cddis.2012.100

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