Antitumor Activities of Kushen: Literature Review

To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in tradit...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Mingyu, Cao, Hongyan, Sun, Lin, Dong, Shu, Bian, Yanqin, Han, Jun, Zhang, Lijun, Ren, Shuang, Hu, Yiyang, Liu, Chenghai, Xu, Lieming, Liu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434675/
https://www.ncbi.nlm.nih.gov/pubmed/22969826
http://dx.doi.org/10.1155/2012/373219
Descripción
Sumario:To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-As in vitro and in vivo. KS-Fs may be developed as novel antitumor agents.

Ejemplares similares