Antitumor Activities of Kushen: Literature Review

To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in tradit...

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Autores principales: Sun, Mingyu, Cao, Hongyan, Sun, Lin, Dong, Shu, Bian, Yanqin, Han, Jun, Zhang, Lijun, Ren, Shuang, Hu, Yiyang, Liu, Chenghai, Xu, Lieming, Liu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434675/
https://www.ncbi.nlm.nih.gov/pubmed/22969826
http://dx.doi.org/10.1155/2012/373219
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author Sun, Mingyu
Cao, Hongyan
Sun, Lin
Dong, Shu
Bian, Yanqin
Han, Jun
Zhang, Lijun
Ren, Shuang
Hu, Yiyang
Liu, Chenghai
Xu, Lieming
Liu, Ping
author_facet Sun, Mingyu
Cao, Hongyan
Sun, Lin
Dong, Shu
Bian, Yanqin
Han, Jun
Zhang, Lijun
Ren, Shuang
Hu, Yiyang
Liu, Chenghai
Xu, Lieming
Liu, Ping
author_sort Sun, Mingyu
collection PubMed
description To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-As in vitro and in vivo. KS-Fs may be developed as novel antitumor agents.
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spelling pubmed-34346752012-09-11 Antitumor Activities of Kushen: Literature Review Sun, Mingyu Cao, Hongyan Sun, Lin Dong, Shu Bian, Yanqin Han, Jun Zhang, Lijun Ren, Shuang Hu, Yiyang Liu, Chenghai Xu, Lieming Liu, Ping Evid Based Complement Alternat Med Review Article To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-As in vitro and in vivo. KS-Fs may be developed as novel antitumor agents. Hindawi Publishing Corporation 2012 2012-08-28 /pmc/articles/PMC3434675/ /pubmed/22969826 http://dx.doi.org/10.1155/2012/373219 Text en Copyright © 2012 Mingyu Sun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sun, Mingyu
Cao, Hongyan
Sun, Lin
Dong, Shu
Bian, Yanqin
Han, Jun
Zhang, Lijun
Ren, Shuang
Hu, Yiyang
Liu, Chenghai
Xu, Lieming
Liu, Ping
Antitumor Activities of Kushen: Literature Review
title Antitumor Activities of Kushen: Literature Review
title_full Antitumor Activities of Kushen: Literature Review
title_fullStr Antitumor Activities of Kushen: Literature Review
title_full_unstemmed Antitumor Activities of Kushen: Literature Review
title_short Antitumor Activities of Kushen: Literature Review
title_sort antitumor activities of kushen: literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434675/
https://www.ncbi.nlm.nih.gov/pubmed/22969826
http://dx.doi.org/10.1155/2012/373219
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