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Immunoglobulin Gene Repertoire in Chronic Lymphocytic Leukemia: Insight into Antigen Selection and Microenvironmental Interactions

Immunogenetic analysis of the B cell receptors (BCRs) has been a richly rewarding field for unraveling the pathogenesis of human lymphomas, including CLL. A biased immunoglobulin gene repertoire is seen as evidence for selection of CLL progenitor cells by antigen. Additional corroborative evidence i...

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Detalles Bibliográficos
Autores principales: Kostareli, Efterpi, Gounari, Maria, Agathangelidis, Andreas, Stamatopoulos, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435129/
https://www.ncbi.nlm.nih.gov/pubmed/22973496
http://dx.doi.org/10.4084/MJHID.2012.052