Rubella Associated with Hemophagocytic Syndrome. First Report in a Male and Review of the Literature

A 22-year-old man was admitted to our hospital because of fever, skin rash and epistaxis. Physical examination revealed fever (39.5°C), generalized purpura, lymphadenopathy and splenomegaly. Blood tests showed pancytopenia. Bone marrow aspiration and biopsy showed hemophagocytosis with no evidence o...

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Detalles Bibliográficos
Autores principales: Koubâa, M., Marrakchi, Ch, Mâaloul, I., Makni, S., Berrajah, L., Elloumi, M., Hammami, B., Lahiani, D., Boudawara, T., Ben Jemâa, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435130/
https://www.ncbi.nlm.nih.gov/pubmed/22973494
http://dx.doi.org/10.4084/MJHID.2012.050
Descripción
Sumario:A 22-year-old man was admitted to our hospital because of fever, skin rash and epistaxis. Physical examination revealed fever (39.5°C), generalized purpura, lymphadenopathy and splenomegaly. Blood tests showed pancytopenia. Bone marrow aspiration and biopsy showed hemophagocytosis with no evidence of malignant cells. Anti rubella IgM antibody were positive and the IgG titers increased from 16 to 50 UI/mL in 3 days. Therefore, he was diagnosed to have rubella-associated hemophagocytic syndrome. We report herein the first case in a man and the sixth case of rubella-associated hemophagocytic syndrome in the literature by search in Pub Med till March 2012.

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