Normal DNA Methylation Dynamics in DICER1-Deficient Mouse Embryonic Stem Cells

Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are required for the proper assembly of heterochromatin. More recent studies have postulated that the reduced methylation is an indirect effect: t...

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Detalles Bibliográficos
Autores principales: Ip, Jonathan, Canham, Paul, Choo, K. H. Andy, Inaba, Yoshimi, Jacobs, Shelley A., Kalitsis, Paul, Mattiske, Deidre M., Ng, Jane, Saffery, Richard, Wong, Nicholas C., Wong, Lee H., Mann, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435250/
https://www.ncbi.nlm.nih.gov/pubmed/22969435
http://dx.doi.org/10.1371/journal.pgen.1002919

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