Correlated Electrostatic Mutations Provide a Reservoir of Stability in HIV Protease

HIV protease, an aspartyl protease crucial to the life cycle of HIV, is the target of many drug development programs. Though many protease inhibitors are on the market, protease eventually evades these drugs by mutating at a rapid pace and building drug resistance. The drug resistance mutations, cal...

Descripción completa

Detalles Bibliográficos
Autores principales: Haq, Omar, Andrec, Michael, Morozov, Alexandre V., Levy, Ronald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435258/
https://www.ncbi.nlm.nih.gov/pubmed/22969420
http://dx.doi.org/10.1371/journal.pcbi.1002675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435258/
https://www.ncbi.nlm.nih.gov/pubmed/22969420
http://dx.doi.org/10.1371/journal.pcbi.1002675

Ejemplares similares