Cargando…
Metabolic Rate Regulates L1 Longevity in C. elegans
Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435313/ https://www.ncbi.nlm.nih.gov/pubmed/22970296 http://dx.doi.org/10.1371/journal.pone.0044720 |
_version_ | 1782242509061095424 |
---|---|
author | Lee, Inhwan Hendrix, Amber Kim, Jeongho Yoshimoto, Jennifer You, Young-Jai |
author_facet | Lee, Inhwan Hendrix, Amber Kim, Jeongho Yoshimoto, Jennifer You, Young-Jai |
author_sort | Lee, Inhwan |
collection | PubMed |
description | Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survival span of arrested L1s, which we call L1 longevity, is a starvation response regulated by metabolic rate during starvation. A high rate of metabolism shortens the L1 survival span, whereas a low rate of metabolism lengthens it. The longer worms are starved, the slower they grow once they are fed, suggesting that L1 arrest has metabolic costs. Furthermore, mutants of genes that regulate metabolism show altered L1 longevity. Among them, we found that AMP-dependent protein kinase (AMPK), as a key energy sensor, regulates L1 longevity by regulating this metabolic arrest. Our results suggest that L1 longevity is determined by metabolic rate and that AMPK as a master regulator of metabolism controls this arrest so that the animals survive long-term starvation. |
format | Online Article Text |
id | pubmed-3435313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34353132012-09-11 Metabolic Rate Regulates L1 Longevity in C. elegans Lee, Inhwan Hendrix, Amber Kim, Jeongho Yoshimoto, Jennifer You, Young-Jai PLoS One Research Article Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C. elegans arrests development at the first larval stage (L1) and survives more than two weeks. Here we show that the survival span of arrested L1s, which we call L1 longevity, is a starvation response regulated by metabolic rate during starvation. A high rate of metabolism shortens the L1 survival span, whereas a low rate of metabolism lengthens it. The longer worms are starved, the slower they grow once they are fed, suggesting that L1 arrest has metabolic costs. Furthermore, mutants of genes that regulate metabolism show altered L1 longevity. Among them, we found that AMP-dependent protein kinase (AMPK), as a key energy sensor, regulates L1 longevity by regulating this metabolic arrest. Our results suggest that L1 longevity is determined by metabolic rate and that AMPK as a master regulator of metabolism controls this arrest so that the animals survive long-term starvation. Public Library of Science 2012-09-06 /pmc/articles/PMC3435313/ /pubmed/22970296 http://dx.doi.org/10.1371/journal.pone.0044720 Text en © 2012 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lee, Inhwan Hendrix, Amber Kim, Jeongho Yoshimoto, Jennifer You, Young-Jai Metabolic Rate Regulates L1 Longevity in C. elegans |
title | Metabolic Rate Regulates L1 Longevity in C. elegans
|
title_full | Metabolic Rate Regulates L1 Longevity in C. elegans
|
title_fullStr | Metabolic Rate Regulates L1 Longevity in C. elegans
|
title_full_unstemmed | Metabolic Rate Regulates L1 Longevity in C. elegans
|
title_short | Metabolic Rate Regulates L1 Longevity in C. elegans
|
title_sort | metabolic rate regulates l1 longevity in c. elegans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435313/ https://www.ncbi.nlm.nih.gov/pubmed/22970296 http://dx.doi.org/10.1371/journal.pone.0044720 |
work_keys_str_mv | AT leeinhwan metabolicrateregulatesl1longevityincelegans AT hendrixamber metabolicrateregulatesl1longevityincelegans AT kimjeongho metabolicrateregulatesl1longevityincelegans AT yoshimotojennifer metabolicrateregulatesl1longevityincelegans AT youyoungjai metabolicrateregulatesl1longevityincelegans |