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P(3)DB: An Integrated Database for Plant Protein Phosphorylation
Protein phosphorylation is widely recognized as the most widespread, enzyme-catalyzed post-translational modification in eukaryotes. In particular, plants have appropriated this signaling mechanism as evidenced by the twofold higher frequency of protein kinases within the genome compared to other eu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435559/ https://www.ncbi.nlm.nih.gov/pubmed/22973285 http://dx.doi.org/10.3389/fpls.2012.00206 |
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author | Yao, Qiuming Bollinger, Curtis Gao, Jianjiong Xu, Dong Thelen, Jay J. |
author_facet | Yao, Qiuming Bollinger, Curtis Gao, Jianjiong Xu, Dong Thelen, Jay J. |
author_sort | Yao, Qiuming |
collection | PubMed |
description | Protein phosphorylation is widely recognized as the most widespread, enzyme-catalyzed post-translational modification in eukaryotes. In particular, plants have appropriated this signaling mechanism as evidenced by the twofold higher frequency of protein kinases within the genome compared to other eukaryotes. While all aspects of plant protein phosphorylation research have grown in the past 10 years; phosphorylation site mapping using high-resolution mass spectrometry has grown exponentially. In Arabidopsis alone there are thousands of experimentally determined phosphorylation sites. To archive these events in a user-intuitive format we have developed P(3)DB, the Plant Protein Phosphorylation Database (p3db.org). This database is a repository for plant protein phosphorylation site data, currently hosting information on 32,963 non-redundant sites collated from 23 experimental studies from six plant species. These data can be queried for a protein-of-interest using an integrated BLAST module to query similar sequences with known phosphorylation sites among the multiple plants currently investigated. The paper demonstrates how this resource can help identify functionally conserved phosphorylation sites in plants using a multi-system approach. |
format | Online Article Text |
id | pubmed-3435559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34355592012-09-12 P(3)DB: An Integrated Database for Plant Protein Phosphorylation Yao, Qiuming Bollinger, Curtis Gao, Jianjiong Xu, Dong Thelen, Jay J. Front Plant Sci Plant Science Protein phosphorylation is widely recognized as the most widespread, enzyme-catalyzed post-translational modification in eukaryotes. In particular, plants have appropriated this signaling mechanism as evidenced by the twofold higher frequency of protein kinases within the genome compared to other eukaryotes. While all aspects of plant protein phosphorylation research have grown in the past 10 years; phosphorylation site mapping using high-resolution mass spectrometry has grown exponentially. In Arabidopsis alone there are thousands of experimentally determined phosphorylation sites. To archive these events in a user-intuitive format we have developed P(3)DB, the Plant Protein Phosphorylation Database (p3db.org). This database is a repository for plant protein phosphorylation site data, currently hosting information on 32,963 non-redundant sites collated from 23 experimental studies from six plant species. These data can be queried for a protein-of-interest using an integrated BLAST module to query similar sequences with known phosphorylation sites among the multiple plants currently investigated. The paper demonstrates how this resource can help identify functionally conserved phosphorylation sites in plants using a multi-system approach. Frontiers Research Foundation 2012-09-07 /pmc/articles/PMC3435559/ /pubmed/22973285 http://dx.doi.org/10.3389/fpls.2012.00206 Text en Copyright © 2012 Yao, Bollinger, Gao, Xu and Thelen. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Plant Science Yao, Qiuming Bollinger, Curtis Gao, Jianjiong Xu, Dong Thelen, Jay J. P(3)DB: An Integrated Database for Plant Protein Phosphorylation |
title | P(3)DB: An Integrated Database for Plant Protein Phosphorylation |
title_full | P(3)DB: An Integrated Database for Plant Protein Phosphorylation |
title_fullStr | P(3)DB: An Integrated Database for Plant Protein Phosphorylation |
title_full_unstemmed | P(3)DB: An Integrated Database for Plant Protein Phosphorylation |
title_short | P(3)DB: An Integrated Database for Plant Protein Phosphorylation |
title_sort | p(3)db: an integrated database for plant protein phosphorylation |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435559/ https://www.ncbi.nlm.nih.gov/pubmed/22973285 http://dx.doi.org/10.3389/fpls.2012.00206 |
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