The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status

SIRT1, a NAD(+)-dependent protein deacetylase, is an important regulator in cellular stress response and energy metabolism. While the list of SIRT1 substrates is growing, how the activity of SIRT1 is regulated remains unclear. We have previously reported that SIRT1 is activated by phosphorylation at...

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Detalles Bibliográficos
Autores principales: Guo, Xiumei, Kesimer, Mehmet, Tolun, Gökhan, Zheng, Xunhai, Xu, Qing, Lu, Jing, Sheehan, John K., Griffith, Jack D., Li, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435561/
https://www.ncbi.nlm.nih.gov/pubmed/22962634
http://dx.doi.org/10.1038/srep00640

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