Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a

Neprilysin is one of the major amyloid-β peptide (Aβ)-degrading enzymes, the expression of which declines in the brain during aging. The decrease in neprilysin leads to a metabolic Aβ imbalance, which can induce the amyloidosis underlying Alzheimer disease. Pharmacological activation of neprilysin d...

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Detalles Bibliográficos
Autores principales: Kakiya, Naomasa, Saito, Takashi, Nilsson, Per, Matsuba, Yukio, Tsubuki, Satoshi, Takei, Nobuyuki, Nawa, Hiroyuki, Saido, Takaomi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436156/
https://www.ncbi.nlm.nih.gov/pubmed/22767595
http://dx.doi.org/10.1074/jbc.M112.340372

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