Cargando…

The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer

AIM: To evaluate the impact of early re-resection on the incidence of tumour recurrence and progression in patients with pT1 high-grade non-muscle invasive bladder cancer (HG-NMIBC). PATIENTS AND METHODS: From 2001 to 2008, 486 consecutive patients were diagnosed with pT1 HG-NMIBC. Data were collect...

Descripción completa

Detalles Bibliográficos
Autores principales: Vasdev, Nikhil, Dominguez-Escrig, Jose, Paez, Edgar, Johnson, Mark I, Durkan, Garrett C, Thorpe, Andrew C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436501/
https://www.ncbi.nlm.nih.gov/pubmed/22988482
http://dx.doi.org/10.3332/ecancer.2012.269
_version_ 1782242648840470528
author Vasdev, Nikhil
Dominguez-Escrig, Jose
Paez, Edgar
Johnson, Mark I
Durkan, Garrett C
Thorpe, Andrew C
author_facet Vasdev, Nikhil
Dominguez-Escrig, Jose
Paez, Edgar
Johnson, Mark I
Durkan, Garrett C
Thorpe, Andrew C
author_sort Vasdev, Nikhil
collection PubMed
description AIM: To evaluate the impact of early re-resection on the incidence of tumour recurrence and progression in patients with pT1 high-grade non-muscle invasive bladder cancer (HG-NMIBC). PATIENTS AND METHODS: From 2001 to 2008, 486 consecutive patients were diagnosed with pT1 HG-NMIBC. Data were collected retrospectively which included patient demographics, histological parameters including the presence of detrusor muscle at initial TUR and at re-resection, adjuvant intravesical therapy, and recurrence and progression rates. Early re-resection was performed within six weeks of initial TUR. Patients comprised those who underwent an early re-resection (Group A, n = 172) and those who did not (Group B, n = 314). RESULTS: At initial TUR, detrusor muscle was present in 61% (n = 105) of patients in Group A and 76% (n = 240) of patients in Group B. At early re-resection, detrusor muscle was present in 77.9% of cases. A residual tumour was present in 54.6% of re-resected cases. The overall incidence of tumour recurrence was 35% and 42% in Groups A and B, respectively. During follow-up, there was a significantly higher rate of tumour stage progression in patients who did not undergo early re-resection (Group B 14.4% vs. Group A 3.3%, P < 0.05). CONCLUSIONS: Early re-resection facilitates accurate staging and clearance of residual disease. Subsequent rates of tumour stage progression are significantly improved. We advocate early re-resection for all patients with HG-NMIBC.
format Online
Article
Text
id pubmed-3436501
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Cancer Intelligence
record_format MEDLINE/PubMed
spelling pubmed-34365012012-09-18 The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer Vasdev, Nikhil Dominguez-Escrig, Jose Paez, Edgar Johnson, Mark I Durkan, Garrett C Thorpe, Andrew C Ecancermedicalscience Research Article AIM: To evaluate the impact of early re-resection on the incidence of tumour recurrence and progression in patients with pT1 high-grade non-muscle invasive bladder cancer (HG-NMIBC). PATIENTS AND METHODS: From 2001 to 2008, 486 consecutive patients were diagnosed with pT1 HG-NMIBC. Data were collected retrospectively which included patient demographics, histological parameters including the presence of detrusor muscle at initial TUR and at re-resection, adjuvant intravesical therapy, and recurrence and progression rates. Early re-resection was performed within six weeks of initial TUR. Patients comprised those who underwent an early re-resection (Group A, n = 172) and those who did not (Group B, n = 314). RESULTS: At initial TUR, detrusor muscle was present in 61% (n = 105) of patients in Group A and 76% (n = 240) of patients in Group B. At early re-resection, detrusor muscle was present in 77.9% of cases. A residual tumour was present in 54.6% of re-resected cases. The overall incidence of tumour recurrence was 35% and 42% in Groups A and B, respectively. During follow-up, there was a significantly higher rate of tumour stage progression in patients who did not undergo early re-resection (Group B 14.4% vs. Group A 3.3%, P < 0.05). CONCLUSIONS: Early re-resection facilitates accurate staging and clearance of residual disease. Subsequent rates of tumour stage progression are significantly improved. We advocate early re-resection for all patients with HG-NMIBC. Cancer Intelligence 2012-09-18 /pmc/articles/PMC3436501/ /pubmed/22988482 http://dx.doi.org/10.3332/ecancer.2012.269 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vasdev, Nikhil
Dominguez-Escrig, Jose
Paez, Edgar
Johnson, Mark I
Durkan, Garrett C
Thorpe, Andrew C
The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer
title The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer
title_full The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer
title_fullStr The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer
title_full_unstemmed The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer
title_short The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer
title_sort impact of early re-resection in patients with pt1 high-grade non-muscle invasive bladder cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436501/
https://www.ncbi.nlm.nih.gov/pubmed/22988482
http://dx.doi.org/10.3332/ecancer.2012.269
work_keys_str_mv AT vasdevnikhil theimpactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT dominguezescrigjose theimpactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT paezedgar theimpactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT johnsonmarki theimpactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT durkangarrettc theimpactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT thorpeandrewc theimpactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT vasdevnikhil impactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT dominguezescrigjose impactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT paezedgar impactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT johnsonmarki impactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT durkangarrettc impactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer
AT thorpeandrewc impactofearlyreresectioninpatientswithpt1highgradenonmuscleinvasivebladdercancer