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Methionine Oxidation Perturbs the Structural Core of the Prion Protein and Suggests a Generic Misfolding Pathway

Oxidative stress and misfolding of the prion protein (PrP(C)) are fundamental to prion diseases. We have therefore probed the effect of oxidation on the structure and stability of PrP(C). Urea unfolding studies indicate that H(2)O(2) oxidation reduces the thermodynamic stability of PrP(C) by as much...

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Detalles Bibliográficos
Autores principales:	Younan, Nadine D., Nadal, Rebecca C., Davies, Paul, Brown, David R., Viles, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436581/ https://www.ncbi.nlm.nih.gov/pubmed/22654104 http://dx.doi.org/10.1074/jbc.M112.354779

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