Breaking Tolerance in Transgenic Mice Expressing the Human TSH Receptor A-Subunit: Thyroiditis, Epitope Spreading and Adjuvant as a ‘Double Edged Sword’

Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before immunization with adenovirus encoding the A-subunit...

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Detalles Bibliográficos
Autores principales: McLachlan, Sandra M., Aliesky, Holly A., Chen, Chun-Rong, Chong, Gao, Rapoport, Basil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436763/
https://www.ncbi.nlm.nih.gov/pubmed/22970131
http://dx.doi.org/10.1371/journal.pone.0043517

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