Cargando…

n-Butylidenephthalide (BP) Maintains Stem Cell Pluripotency by Activating Jak2/Stat3 Pathway and Increases the Efficiency of iPS Cells Generation

In 2006, induced pluripotent stem (iPS) cells were generated from somatic cells by introducing Oct4, Sox2, c-Myc and Klf4. The original process was inefficient; maintaining the pluripotency of embryonic stem (ES) and iPS cell cultures required an expensive reagent–leukemia induced factor (LIF). Our...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shih-Ping, Harn, Horng-Jyh, Chien, Ying-Jiun, Chang, Cheng-Hsuan, Hsu, Chien-Yu, Fu, Ru-Huei, Huang, Yu-Chuen, Chen, Shih-Yin, Shyu, Woei-Cherng, Lin, Shinn-Zong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436873/ https://www.ncbi.nlm.nih.gov/pubmed/22970157 http://dx.doi.org/10.1371/journal.pone.0044024

Ejemplares similares

n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease
por: Fu, Ru-Huei, et al.
Publicado: (2014)

The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration
por: Chuang, Hong-Meng, et al.
Publicado: (2016)

The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency
por: Wang, Chie-Hong, et al.
Publicado: (2020)

n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma
por: Yen, Ssu-Yin, et al.
Publicado: (2017)

Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas
por: Chen, Pei-Yin, et al.
Publicado: (2022)

Targeting the Axl and mTOR Pathway Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a Recurrent GBM
por: Liu, Ching-Ann, et al.
Publicado: (2022)

Sambucus williamsii induced embryonic stem cells differentiated into neurons
por: Liu, Shih-Ping, et al.
Publicado: (2015)

N-butylidenephthalide Attenuates Alzheimer's Disease-Like Cytopathy in Down Syndrome Induced Pluripotent Stem Cell-Derived Neurons
por: Chang, Chia-Yu, et al.
Publicado: (2015)

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide
por: Chiu, Sheng-Chun, et al.
Publicado: (2012)

n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
por: Lee, Jui-Hao, et al.
Publicado: (2021)

Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide
por: Chuang, Hong-Meng, et al.
Publicado: (2018)

Adipose-derived Stem Cells Stimulated with n-Butylidenephthalide Exhibit Therapeutic Effects in a Mouse Model of Parkinson’s Disease
por: Chi, Kang, et al.
Publicado: (2018)

The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo3
por: Tsai, Nu-Man, et al.
Publicado: (2006)

Acetylcorynoline Impairs the Maturation of Mouse Bone Marrow-Derived Dendritic Cells via Suppression of IκB Kinase and Mitogen-Activated Protein Kinase Activities
por: Fu, Ru-Huei, et al.
Publicado: (2013)

N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model
por: Yang, Hsin-Han, et al.
Publicado: (2020)

Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages
por: Chang, Chia-Yu, et al.
Publicado: (2021)

Induced Pluripotent Stem Cells: A Powerful Neurodegenerative Disease Modeling Tool for Mechanism Study and Drug Discovery
por: Chang, Chia-Yu, et al.
Publicado: (2018)

Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling
por: Ting, Hsiao-Chien, et al.
Publicado: (2022)

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening
por: Chang, Chia-Yu, et al.
Publicado: (2020)

Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson’s Disease
por: Tsai, Chia-Wen, et al.
Publicado: (2018)

Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
por: Lee, Jui-Hao, et al.
Publicado: (2018)

Cbx7 promotes the generation of induced pluripotent stem cells
por: Wang, Chie-Hong, et al.
Publicado: (2023)

C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect
por: Fu, Ru-Huei, et al.
Publicado: (2022)

Interaction of a Novel Alternatively Spliced Variant of HSD11B1L with Parkin Enhances the Carcinogenesis Potential of Glioblastoma: Peiminine Interferes with This Interaction
por: Fu, Ru-Huei, et al.
Publicado: (2023)

Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats
por: Shih, Chung-Hung, et al.
Publicado: (2015)

The Protective Effects of n-Butylidenephthalide on Retinal Ganglion Cells during Ischemic Injury
por: Chou, Yu-Yau, et al.
Publicado: (2022)

Mechanisms of butylidenephthalide for twitch facilitation in electrically stimulated mouse vas deferens
por: Shih, Chung-Hung, et al.
Publicado: (2018)

Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs
por: Yang, Hsin-Han, et al.
Publicado: (2022)

Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells
por: Chang, Kai-Fu, et al.
Publicado: (2020)

Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson’s Disease Models In Vivo and In Vitro
por: Hsu, Yu-Ling, et al.
Publicado: (2021)

Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia
por: Hsieh, Jeanne, et al.
Publicado: (2017)

A Novel Splice Variant of BCAS1 Inhibits β-Arrestin 2 to Promote the Proliferation and Migration of Glioblastoma Cells, and This Effect Was Blocked by Maackiain
por: Kuo, Yun-Hua, et al.
Publicado: (2022)

Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson’s Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway
por: Fu, Ru-Huei, et al.
Publicado: (2022)

Identifying Therapeutic Targets for Spinocerebellar Ataxia Type 3/Machado–Joseph Disease through Integration of Pathological Biomarkers and Therapeutic Strategies
por: Chen, Yu-Shuan, et al.
Publicado: (2020)

The Molecular Mechanisms of Plant-Derived Compounds Targeting Brain Cancer
por: Fan, Hueng-Chuen, et al.
Publicado: (2018)

Downregulation of DAB2IP Promotes Mesenchymal-To-Neuroepithelial Transition and Neuronal Differentiation of Human Mesenchymal Stem Cells
por: Chang, Sunny Li-Yun, et al.
Publicado: (2013)

Butylidenephthalide facilitates contractions via nonspecific binding to receptors in isolated guinea-pig vas deferens
por: Shih, Chung-Hung, et al.
Publicado: (2019)

Predictors of Response to Autologous Dendritic Cell Therapy in Glioblastoma Multiforme
por: Jan, Chia-Ing, et al.
Publicado: (2018)

Targeting Cellular Stress Mechanisms and Metabolic Homeostasis by Chinese Herbal Drugs for Neuroprotection
por: Ting, Hsiao-Chien, et al.
Publicado: (2018)

The Role of Gene Editing in Neurodegenerative Diseases
por: Fan, Hueng-Chuen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tpmgfqmj7mqvlijoivpcnl39d6