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Neurological perspectives on voltage-gated sodium channels

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as m...

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Autores principales: Eijkelkamp, Niels, Linley, John E., Baker, Mark D., Minett, Michael S., Cregg, Roman, Werdehausen, Robert, Rugiero, François, Wood, John N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437034/
https://www.ncbi.nlm.nih.gov/pubmed/22961543
http://dx.doi.org/10.1093/brain/aws225
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author Eijkelkamp, Niels
Linley, John E.
Baker, Mark D.
Minett, Michael S.
Cregg, Roman
Werdehausen, Robert
Rugiero, François
Wood, John N.
author_facet Eijkelkamp, Niels
Linley, John E.
Baker, Mark D.
Minett, Michael S.
Cregg, Roman
Werdehausen, Robert
Rugiero, François
Wood, John N.
author_sort Eijkelkamp, Niels
collection PubMed
description The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.
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spelling pubmed-34370342012-09-10 Neurological perspectives on voltage-gated sodium channels Eijkelkamp, Niels Linley, John E. Baker, Mark D. Minett, Michael S. Cregg, Roman Werdehausen, Robert Rugiero, François Wood, John N. Brain Review Article The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors. Oxford University Press 2012-09 2012-08-29 /pmc/articles/PMC3437034/ /pubmed/22961543 http://dx.doi.org/10.1093/brain/aws225 Text en © The Author 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Eijkelkamp, Niels
Linley, John E.
Baker, Mark D.
Minett, Michael S.
Cregg, Roman
Werdehausen, Robert
Rugiero, François
Wood, John N.
Neurological perspectives on voltage-gated sodium channels
title Neurological perspectives on voltage-gated sodium channels
title_full Neurological perspectives on voltage-gated sodium channels
title_fullStr Neurological perspectives on voltage-gated sodium channels
title_full_unstemmed Neurological perspectives on voltage-gated sodium channels
title_short Neurological perspectives on voltage-gated sodium channels
title_sort neurological perspectives on voltage-gated sodium channels
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437034/
https://www.ncbi.nlm.nih.gov/pubmed/22961543
http://dx.doi.org/10.1093/brain/aws225
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