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Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology

BACKGROUND: The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide information on factors linked with disease development. We investigated putative a...

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Autores principales: McNally, Richard J Q, Blakey, Karen, Parslow, Roger C, James, Peter W, Pozo, Basilio Gómez, Stiller, Charles, Vincent, Tim J, Norman, Paul, McKinney, Patricia A, Murphy, Michael F, Craft, Alan W, Feltbower, Richard G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437194/
https://www.ncbi.nlm.nih.gov/pubmed/22738416
http://dx.doi.org/10.1186/1471-2407-12-270
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author McNally, Richard J Q
Blakey, Karen
Parslow, Roger C
James, Peter W
Pozo, Basilio Gómez
Stiller, Charles
Vincent, Tim J
Norman, Paul
McKinney, Patricia A
Murphy, Michael F
Craft, Alan W
Feltbower, Richard G
author_facet McNally, Richard J Q
Blakey, Karen
Parslow, Roger C
James, Peter W
Pozo, Basilio Gómez
Stiller, Charles
Vincent, Tim J
Norman, Paul
McKinney, Patricia A
Murphy, Michael F
Craft, Alan W
Feltbower, Richard G
author_sort McNally, Richard J Q
collection PubMed
description BACKGROUND: The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide information on factors linked with disease development. We investigated putative associations with deprivation and population density. METHODS: Data on osteosarcoma and Ewing sarcoma were obtained from national population-based registries. Negative binomial regression was used to examine the relationship between incidence rates and the Townsend deprivation score (and its component variables) and small-area population density. RESULTS: The study analyzed 2566 osteosarcoma and 1650 Ewing sarcoma cases. For females with osteosarcoma, statistically significant decreased risk was associated with higher levels of deprivation (relative risk [RR] per unit increase in deprivation score = 0.969; 95% confidence interval [CI] 0.946–0.993). For all Ewing sarcoma combined, statistically significant decreased risk was associated with greater area-level population density and higher levels of non-car ownership (RR per person per hectare increase = 0.984; 95% CI 0.976–0.993, RR per 1% increase in non-car ownership = 0.994; 95% CI 0.991–0.998). CONCLUSIONS: Higher incidence of osteosarcoma was observed for females in areas with lower deprivation levels indicating increased risk is linked to some aspect of affluent living. Higher incidence of Ewing sarcoma occurred in areas of low population density and where more people owned cars, both characteristic of rural environments. The study adds substantially to evidence associating Ewing sarcoma risk with rural environmental exposures. Putative risk factors include agricultural exposures, such as pesticides and zoonotic agents.
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spelling pubmed-34371942012-09-09 Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology McNally, Richard J Q Blakey, Karen Parslow, Roger C James, Peter W Pozo, Basilio Gómez Stiller, Charles Vincent, Tim J Norman, Paul McKinney, Patricia A Murphy, Michael F Craft, Alan W Feltbower, Richard G BMC Cancer Research Article BACKGROUND: The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide information on factors linked with disease development. We investigated putative associations with deprivation and population density. METHODS: Data on osteosarcoma and Ewing sarcoma were obtained from national population-based registries. Negative binomial regression was used to examine the relationship between incidence rates and the Townsend deprivation score (and its component variables) and small-area population density. RESULTS: The study analyzed 2566 osteosarcoma and 1650 Ewing sarcoma cases. For females with osteosarcoma, statistically significant decreased risk was associated with higher levels of deprivation (relative risk [RR] per unit increase in deprivation score = 0.969; 95% confidence interval [CI] 0.946–0.993). For all Ewing sarcoma combined, statistically significant decreased risk was associated with greater area-level population density and higher levels of non-car ownership (RR per person per hectare increase = 0.984; 95% CI 0.976–0.993, RR per 1% increase in non-car ownership = 0.994; 95% CI 0.991–0.998). CONCLUSIONS: Higher incidence of osteosarcoma was observed for females in areas with lower deprivation levels indicating increased risk is linked to some aspect of affluent living. Higher incidence of Ewing sarcoma occurred in areas of low population density and where more people owned cars, both characteristic of rural environments. The study adds substantially to evidence associating Ewing sarcoma risk with rural environmental exposures. Putative risk factors include agricultural exposures, such as pesticides and zoonotic agents. BioMed Central 2012-06-27 /pmc/articles/PMC3437194/ /pubmed/22738416 http://dx.doi.org/10.1186/1471-2407-12-270 Text en Copyright ©2012 McNally et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
McNally, Richard J Q
Blakey, Karen
Parslow, Roger C
James, Peter W
Pozo, Basilio Gómez
Stiller, Charles
Vincent, Tim J
Norman, Paul
McKinney, Patricia A
Murphy, Michael F
Craft, Alan W
Feltbower, Richard G
Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
title Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
title_full Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
title_fullStr Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
title_full_unstemmed Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
title_short Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
title_sort small-area analyses of bone cancer diagnosed in great britain provide clues to aetiology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437194/
https://www.ncbi.nlm.nih.gov/pubmed/22738416
http://dx.doi.org/10.1186/1471-2407-12-270
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