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Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
BACKGROUND: The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide information on factors linked with disease development. We investigated putative a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437194/ https://www.ncbi.nlm.nih.gov/pubmed/22738416 http://dx.doi.org/10.1186/1471-2407-12-270 |
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author | McNally, Richard J Q Blakey, Karen Parslow, Roger C James, Peter W Pozo, Basilio Gómez Stiller, Charles Vincent, Tim J Norman, Paul McKinney, Patricia A Murphy, Michael F Craft, Alan W Feltbower, Richard G |
author_facet | McNally, Richard J Q Blakey, Karen Parslow, Roger C James, Peter W Pozo, Basilio Gómez Stiller, Charles Vincent, Tim J Norman, Paul McKinney, Patricia A Murphy, Michael F Craft, Alan W Feltbower, Richard G |
author_sort | McNally, Richard J Q |
collection | PubMed |
description | BACKGROUND: The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide information on factors linked with disease development. We investigated putative associations with deprivation and population density. METHODS: Data on osteosarcoma and Ewing sarcoma were obtained from national population-based registries. Negative binomial regression was used to examine the relationship between incidence rates and the Townsend deprivation score (and its component variables) and small-area population density. RESULTS: The study analyzed 2566 osteosarcoma and 1650 Ewing sarcoma cases. For females with osteosarcoma, statistically significant decreased risk was associated with higher levels of deprivation (relative risk [RR] per unit increase in deprivation score = 0.969; 95% confidence interval [CI] 0.946–0.993). For all Ewing sarcoma combined, statistically significant decreased risk was associated with greater area-level population density and higher levels of non-car ownership (RR per person per hectare increase = 0.984; 95% CI 0.976–0.993, RR per 1% increase in non-car ownership = 0.994; 95% CI 0.991–0.998). CONCLUSIONS: Higher incidence of osteosarcoma was observed for females in areas with lower deprivation levels indicating increased risk is linked to some aspect of affluent living. Higher incidence of Ewing sarcoma occurred in areas of low population density and where more people owned cars, both characteristic of rural environments. The study adds substantially to evidence associating Ewing sarcoma risk with rural environmental exposures. Putative risk factors include agricultural exposures, such as pesticides and zoonotic agents. |
format | Online Article Text |
id | pubmed-3437194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34371942012-09-09 Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology McNally, Richard J Q Blakey, Karen Parslow, Roger C James, Peter W Pozo, Basilio Gómez Stiller, Charles Vincent, Tim J Norman, Paul McKinney, Patricia A Murphy, Michael F Craft, Alan W Feltbower, Richard G BMC Cancer Research Article BACKGROUND: The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide information on factors linked with disease development. We investigated putative associations with deprivation and population density. METHODS: Data on osteosarcoma and Ewing sarcoma were obtained from national population-based registries. Negative binomial regression was used to examine the relationship between incidence rates and the Townsend deprivation score (and its component variables) and small-area population density. RESULTS: The study analyzed 2566 osteosarcoma and 1650 Ewing sarcoma cases. For females with osteosarcoma, statistically significant decreased risk was associated with higher levels of deprivation (relative risk [RR] per unit increase in deprivation score = 0.969; 95% confidence interval [CI] 0.946–0.993). For all Ewing sarcoma combined, statistically significant decreased risk was associated with greater area-level population density and higher levels of non-car ownership (RR per person per hectare increase = 0.984; 95% CI 0.976–0.993, RR per 1% increase in non-car ownership = 0.994; 95% CI 0.991–0.998). CONCLUSIONS: Higher incidence of osteosarcoma was observed for females in areas with lower deprivation levels indicating increased risk is linked to some aspect of affluent living. Higher incidence of Ewing sarcoma occurred in areas of low population density and where more people owned cars, both characteristic of rural environments. The study adds substantially to evidence associating Ewing sarcoma risk with rural environmental exposures. Putative risk factors include agricultural exposures, such as pesticides and zoonotic agents. BioMed Central 2012-06-27 /pmc/articles/PMC3437194/ /pubmed/22738416 http://dx.doi.org/10.1186/1471-2407-12-270 Text en Copyright ©2012 McNally et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article McNally, Richard J Q Blakey, Karen Parslow, Roger C James, Peter W Pozo, Basilio Gómez Stiller, Charles Vincent, Tim J Norman, Paul McKinney, Patricia A Murphy, Michael F Craft, Alan W Feltbower, Richard G Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology |
title | Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology |
title_full | Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology |
title_fullStr | Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology |
title_full_unstemmed | Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology |
title_short | Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology |
title_sort | small-area analyses of bone cancer diagnosed in great britain provide clues to aetiology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437194/ https://www.ncbi.nlm.nih.gov/pubmed/22738416 http://dx.doi.org/10.1186/1471-2407-12-270 |
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